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Research Article

Loss of Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) Reveals a Requirement for MAPK Signalling in Mouse Sex Determination

  • Debora Bogani,

    Affiliation: Mammalian Genetics Unit, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom

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  • Pam Siggers,

    Affiliation: Mammalian Genetics Unit, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom

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  • Rachel Brixey,

    Affiliation: Mammalian Genetics Unit, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom

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  • Nick Warr,

    Affiliation: Mammalian Genetics Unit, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom

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  • Sarah Beddow,

    Affiliation: Mammalian Genetics Unit, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom

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  • Jessica Edwards,

    Affiliation: Mammalian Genetics Unit, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom

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  • Debbie Williams,

    Affiliation: Mammalian Genetics Unit, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom

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  • Dagmar Wilhelm,

    Affiliation: The Institute of Molecular Bioscience, University of Queensland, Brisbane, Australia

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  • Peter Koopman,

    Affiliation: The Institute of Molecular Bioscience, University of Queensland, Brisbane, Australia

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  • Richard A. Flavell,

    Affiliation: Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Hongbo Chi,

    Affiliation: Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Harry Ostrer,

    Affiliation: Human Genetics Program, New York University School of Medicine, New York, New York, United States of America

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  • Sara Wells,

    Affiliation: The Mary Lyon Centre, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom

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  • Michael Cheeseman,

    Affiliations: Mammalian Genetics Unit, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom, The Mary Lyon Centre, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom

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  • Andy Greenfield mail

    a.greenfield@har.mrc.ac.uk

    Affiliation: Mammalian Genetics Unit, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom

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  • Published: September 15, 2009
  • DOI: 10.1371/journal.pbio.1000196

About the Authors

Debora Bogani, Pam Siggers, Rachel Brixey, Nick Warr, Sarah Beddow, Jessica Edwards, Debbie Williams, Michael Cheeseman, Andy Greenfield
Mammalian Genetics Unit, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom
Dagmar Wilhelm, Peter Koopman
The Institute of Molecular Bioscience, University of Queensland, Brisbane, Australia
Richard A. Flavell
Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America
Hongbo Chi
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
Harry Ostrer
Human Genetics Program, New York University School of Medicine, New York, New York, United States of America
Sara Wells, Michael Cheeseman
The Mary Lyon Centre, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom

Corresponding Author

Email: a.greenfield@har.mrc.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: DB PS RB NW DW MC AG. Performed the experiments: DB PS RB NW SB JE DW SW MC. Analyzed the data: DB PS RB NW DW MC AG. Contributed reagents/materials/analysis tools: DW PK RAF HC HO. Wrote the paper: AG.