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Research Article

Regulated Fluctuations in Nanog Expression Mediate Cell Fate Decisions in Embryonic Stem Cells

  • Tibor Kalmar equal contributor,

    equal contributor Contributed equally to this work with: Tibor Kalmar, Chea Lim, Penelope Hayward

    Affiliation: Department of Genetics, University of Cambridge, Cambridge, United Kingdom

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  • Chea Lim equal contributor,

    equal contributor Contributed equally to this work with: Tibor Kalmar, Chea Lim, Penelope Hayward

    Affiliation: Department of Genetics, University of Cambridge, Cambridge, United Kingdom

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  • Penelope Hayward equal contributor,

    equal contributor Contributed equally to this work with: Tibor Kalmar, Chea Lim, Penelope Hayward

    Affiliation: Department of Genetics, University of Cambridge, Cambridge, United Kingdom

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  • Silvia Muñoz-Descalzo,

    Affiliation: Department of Genetics, University of Cambridge, Cambridge, United Kingdom

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  • Jennifer Nichols,

    Affiliation: Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, United Kingdom

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  • Jordi Garcia-Ojalvo,

    Affiliation: Departament de Fisica i Enginyeria Nuclear, Universitat Politecnica de Catalunya, Colom 11, Terrassa, Spain

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  • Alfonso Martinez Arias mail

    ama11@hermes.cam.ac.uk

    Affiliation: Department of Genetics, University of Cambridge, Cambridge, United Kingdom

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  • Published: July 07, 2009
  • DOI: 10.1371/journal.pbio.1000149

About the Authors

Tibor Kalmar, Chea Lim, Penelope Hayward, Silvia Muñoz-Descalzo, Alfonso Martinez Arias
Department of Genetics, University of Cambridge, Cambridge, United Kingdom
Jennifer Nichols
Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, United Kingdom
Jordi Garcia-Ojalvo
Departament de Fisica i Enginyeria Nuclear, Universitat Politecnica de Catalunya, Colom 11, Terrassa, Spain

Corresponding Author

Email: ama11@hermes.cam.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: TK CL PH AMA. Performed the experiments: TK CL PH SM-D JN. Analyzed the data: TK CL PH JN JG-O AMA. Contributed reagents/materials/analysis tools: TK. Wrote the paper: TK JG-O AMA. Developed the model: JG-O AMA.