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Research Article

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

  • Elton Zeqiraj,

    Affiliations: Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, Scotland, MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland

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  • Beatrice Maria Filippi,

    Affiliation: MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland

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  • Simon Goldie,

    Affiliations: Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, Scotland, MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland

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  • Iva Navratilova,

    Affiliation: Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland

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  • Jérôme Boudeau,

    Affiliation: MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland

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  • Maria Deak,

    Affiliation: MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland

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  • Dario R. Alessi,

    Affiliation: MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland

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  • Daan M. F. van Aalten mail

    dmfvanaalten@dundee.ac.uk

    Affiliation: Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, Scotland

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  • Published: June 09, 2009
  • DOI: 10.1371/journal.pbio.1000126

About the Authors

Elton Zeqiraj, Simon Goldie, Daan M. F. van Aalten
Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, Scotland
Elton Zeqiraj, Beatrice Maria Filippi, Simon Goldie, Jérôme Boudeau, Maria Deak, Dario R. Alessi
MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland
Iva Navratilova
Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland

Corresponding Author

Email: dmfvanaalten@dundee.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: EZ BMF DRA DMFvA. Performed the experiments: EZ BMF SG IN JB MD DMFvA. Analyzed the data: EZ BMF IN DRA DMFvA. Wrote the paper: EZ DRA DMFvA.