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Research Article

The Hierarchy of Exon-Junction Complex Assembly by the Spliceosome Explains Key Features of Mammalian Nonsense-Mediated mRNA Decay

  • Niels H. Gehring mail,

    Niels.Gehring@med.uni-heidelberg.de (NHG); Andreas.Kulozik@med.uni-heidelberg.de (AEK)

    Affiliations: Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, Heidelberg, Germany, Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany, European Molecular Biology Laboratory, Heidelberg, Germany

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  • Styliani Lamprinaki,

    Affiliations: Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, Heidelberg, Germany, European Molecular Biology Laboratory, Heidelberg, Germany

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  • Matthias W. Hentze,

    Affiliations: Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, Heidelberg, Germany, European Molecular Biology Laboratory, Heidelberg, Germany

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  • Andreas E. Kulozik mail

    Niels.Gehring@med.uni-heidelberg.de (NHG); Andreas.Kulozik@med.uni-heidelberg.de (AEK)

    Affiliations: Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, Heidelberg, Germany, Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany

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  • Published: May 26, 2009
  • DOI: 10.1371/journal.pbio.1000120

About the Authors

Niels H. Gehring, Styliani Lamprinaki, Matthias W. Hentze, Andreas E. Kulozik
Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, Heidelberg, Germany
Niels H. Gehring, Andreas E. Kulozik
Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany
Niels H. Gehring, Styliani Lamprinaki, Matthias W. Hentze
European Molecular Biology Laboratory, Heidelberg, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: NHG. Performed the experiments: NHG SL. Analyzed the data: NHG MWH AEK. Contributed reagents/materials/analysis tools: NHG SL. Wrote the paper: NHG MWH AEK.