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Research Article

Transcriptional Dysregulation in NIPBL and Cohesin Mutant Human Cells

  • Jinglan Liu,

    Affiliation: Division of Human Genetics, Abramson Research Institute, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

    X
  • Zhe Zhang,

    Affiliation: Center for Biomedical Informatics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

    X
  • Masashige Bando,

    Affiliation: Laboratory of Chromosome Structure and Function, Department of Biological Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama City, Kanagawa, Japan

    X
  • Takehiko Itoh,

    Affiliation: Laboratory of Chromosome Structure and Function, Department of Biological Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama City, Kanagawa, Japan

    X
  • Matthew A. Deardorff,

    Affiliations: Division of Human Genetics, Abramson Research Institute, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Dinah Clark,

    Affiliation: Division of Human Genetics, Abramson Research Institute, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

    X
  • Maninder Kaur,

    Affiliation: Division of Human Genetics, Abramson Research Institute, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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  • Stephany Tandy,

    Affiliation: Division of Human Genetics, Abramson Research Institute, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

    X
  • Tatsuro Kondoh,

    Affiliation: Division of Developmental Disability, Misakaenosono Mutsumi Developmental, Medical, and Welfare Center, Isahaya, Japan

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  • Eric Rappaport,

    Affiliation: NAPCORE, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

    X
  • Nancy B. Spinner,

    Affiliations: Division of Human Genetics, Abramson Research Institute, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Hugo Vega,

    Affiliation: Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia

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  • Laird G. Jackson,

    Affiliation: Department of Obstetrics and Gynecology, Drexel University School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Katsuhiko Shirahige,

    Affiliation: Laboratory of Chromosome Structure and Function, Department of Biological Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama City, Kanagawa, Japan

    X
  • Ian D. Krantz mail

    ian2@mail.med.upenn.edu

    Affiliations: Division of Human Genetics, Abramson Research Institute, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Published: May 26, 2009
  • DOI: 10.1371/journal.pbio.1000119

About the Authors

Jinglan Liu, Matthew A. Deardorff, Dinah Clark, Maninder Kaur, Stephany Tandy, Nancy B. Spinner, Ian D. Krantz
Division of Human Genetics, Abramson Research Institute, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
Zhe Zhang
Center for Biomedical Informatics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
Masashige Bando, Takehiko Itoh, Katsuhiko Shirahige
Laboratory of Chromosome Structure and Function, Department of Biological Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama City, Kanagawa, Japan
Matthew A. Deardorff, Nancy B. Spinner, Ian D. Krantz
The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
Tatsuro Kondoh
Division of Developmental Disability, Misakaenosono Mutsumi Developmental, Medical, and Welfare Center, Isahaya, Japan
Eric Rappaport
NAPCORE, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
Hugo Vega
Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia
Laird G. Jackson
Department of Obstetrics and Gynecology, Drexel University School of Medicine, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: ian2@mail.med.upenn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: KS IDK. Performed the experiments: JL MB TI. Analyzed the data: JL ZZ MB. Contributed reagents/materials/analysis tools: MAD DC MK ST TK ER NBS HV LGJ. Wrote the paper: JL ZZ IDK. Figure preparation: ZZ JL KS IDK.