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Research Article

Lineage-Specific Biology Revealed by a Finished Genome Assembly of the Mouse

  • Deanna M. Church equal contributor mail,

    equal contributor Contributed equally to this work with: Deanna M. Church, Leo Goodstadt

    church@ncbi.nlm.nih.gov (DMC); plos@llew.org.uk (LG); kersli@broad.mit.edu (KL-T); eee@gs.washington.edu (EEE); chris.ponting@dpag.ox.ac.uk (CPP)

    Affiliation: National Center for Biotechnology Information, Bethesda, Maryland, United States of America

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  • Leo Goodstadt equal contributor mail,

    equal contributor Contributed equally to this work with: Deanna M. Church, Leo Goodstadt

    church@ncbi.nlm.nih.gov (DMC); plos@llew.org.uk (LG); kersli@broad.mit.edu (KL-T); eee@gs.washington.edu (EEE); chris.ponting@dpag.ox.ac.uk (CPP)

    Affiliation: MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom

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  • LaDeana W. Hillier,

    Affiliation: The Genome Center at Washington University, St. Louis, Missouri, United States of America

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  • Michael C. Zody,

    Affiliations: The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden

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  • Steve Goldstein,

    Affiliation: Laboratory for Molecular and Computational Genomics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Xinwe She,

    Affiliation: Department of Genome Sciences and Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States of America

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  • Carol J. Bult,

    Affiliation: The Jackson Laboratory, Bar Harbor, Maine, United States of America

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  • Richa Agarwala,

    Affiliation: National Center for Biotechnology Information, Bethesda, Maryland, United States of America

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  • Joshua L. Cherry,

    Affiliation: National Center for Biotechnology Information, Bethesda, Maryland, United States of America

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  • Michael DiCuccio,

    Affiliation: National Center for Biotechnology Information, Bethesda, Maryland, United States of America

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  • Wratko Hlavina,

    Affiliation: National Center for Biotechnology Information, Bethesda, Maryland, United States of America

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  • Yuri Kapustin,

    Affiliation: National Center for Biotechnology Information, Bethesda, Maryland, United States of America

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  • Peter Meric,

    Affiliation: National Center for Biotechnology Information, Bethesda, Maryland, United States of America

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  • Donna Maglott,

    Affiliation: National Center for Biotechnology Information, Bethesda, Maryland, United States of America

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  • Zoë Birtle,

    Affiliation: MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom

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  • Ana C. Marques,

    Affiliation: MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom

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  • Tina Graves,

    Affiliation: The Genome Center at Washington University, St. Louis, Missouri, United States of America

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  • Shiguo Zhou,

    Affiliation: Laboratory for Molecular and Computational Genomics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Brian Teague,

    Affiliation: Laboratory for Molecular and Computational Genomics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Konstantinos Potamousis,

    Affiliation: Laboratory for Molecular and Computational Genomics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Christopher Churas,

    Affiliation: Laboratory for Molecular and Computational Genomics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Michael Place,

    Affiliation: Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Jill Herschleb,

    Affiliation: Laboratory for Molecular and Computational Genomics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Ron Runnheim,

    Affiliation: Laboratory for Molecular and Computational Genomics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Daniel Forrest,

    Affiliation: Laboratory for Molecular and Computational Genomics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • James Amos-Landgraf,

    Affiliation: McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

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  • David C. Schwartz,

    Affiliation: Laboratory for Molecular and Computational Genomics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Ze Cheng,

    Affiliation: Department of Genome Sciences and Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States of America

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  • Kerstin Lindblad-Toh mail,

    church@ncbi.nlm.nih.gov (DMC); plos@llew.org.uk (LG); kersli@broad.mit.edu (KL-T); eee@gs.washington.edu (EEE); chris.ponting@dpag.ox.ac.uk (CPP)

    Affiliations: The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden

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  • Evan E. Eichler mail,

    church@ncbi.nlm.nih.gov (DMC); plos@llew.org.uk (LG); kersli@broad.mit.edu (KL-T); eee@gs.washington.edu (EEE); chris.ponting@dpag.ox.ac.uk (CPP)

    Affiliation: Department of Genome Sciences and Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States of America

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  • Chris P. Ponting mail,

    church@ncbi.nlm.nih.gov (DMC); plos@llew.org.uk (LG); kersli@broad.mit.edu (KL-T); eee@gs.washington.edu (EEE); chris.ponting@dpag.ox.ac.uk (CPP)

    Affiliation: MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom

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  • The Mouse Genome Sequencing Consortium

    Membership of The Mouse Genome Sequencing Consortium is provided in the Acknowledgments.

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  • Published: May 26, 2009
  • DOI: 10.1371/journal.pbio.1000112

About the Authors

Deanna M. Church, Richa Agarwala, Joshua L. Cherry, Michael DiCuccio, Wratko Hlavina, Yuri Kapustin, Peter Meric, Donna Maglott
National Center for Biotechnology Information, Bethesda, Maryland, United States of America
Leo Goodstadt, Zoë Birtle, Ana C. Marques, Chris P. Ponting
MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
LaDeana W. Hillier, Tina Graves
The Genome Center at Washington University, St. Louis, Missouri, United States of America
Michael C. Zody, Kerstin Lindblad-Toh
The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
Michael C. Zody, Kerstin Lindblad-Toh
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
Steve Goldstein, Shiguo Zhou, Brian Teague, Konstantinos Potamousis, Christopher Churas, Jill Herschleb, Ron Runnheim, Daniel Forrest, David C. Schwartz
Laboratory for Molecular and Computational Genomics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
Xinwe She, Ze Cheng, Evan E. Eichler
Department of Genome Sciences and Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States of America
Carol J. Bult
The Jackson Laboratory, Bar Harbor, Maine, United States of America
Michael Place
Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
James Amos-Landgraf
McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: DMC LG DCS KLT CPP. Performed the experiments: DMC LG LWH MZ SG XS CJB RA JLC MD WH YK PM DM ZB ACM TG SZ BT KP CC MP JH RR DF JAL ZC TMGSC. Analyzed the data: DMC LG LWH MZ SG XS CJB DCS ZC EEE CPP. Contributed reagents/materials/analysis tools: DMC LG. Wrote the paper: DMC LG LWH MZ KLT EEE CPP.