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Research Article

Plk1 Self-Organization and Priming Phosphorylation of HsCYK-4 at the Spindle Midzone Regulate the Onset of Division in Human Cells

  • Mark E. Burkard,

    Affiliations: Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

    Current address: Department of Medicine, University of Wisconsin, Madison, Wisconsin, United States of America

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  • John Maciejowski,

    Affiliation: Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • Verónica Rodriguez-Bravo,

    Affiliation: Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • Michael Repka,

    Affiliation: Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • Drew M. Lowery,

    Affiliation: Departments of Biology and Biological Engineering, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Karl R. Clauser,

    Affiliation: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Chao Zhang,

    Affiliations: Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California, United States of America, Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, California, United States of America

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  • Kevan M. Shokat,

    Affiliations: Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California, United States of America, Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, California, United States of America

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  • Steven A. Carr,

    Affiliation: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Michael B. Yaffe,

    Affiliations: Departments of Biology and Biological Engineering, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Prasad V. Jallepalli mail

    jallepap@mskcc.org

    Affiliation: Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • Published: May 26, 2009
  • DOI: 10.1371/journal.pbio.1000111

About the Authors

Mark E. Burkard, John Maciejowski, Verónica Rodriguez-Bravo, Michael Repka, Prasad V. Jallepalli
Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
Mark E. Burkard
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
Drew M. Lowery, Michael B. Yaffe
Departments of Biology and Biological Engineering, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Karl R. Clauser, Steven A. Carr, Michael B. Yaffe
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
Chao Zhang, Kevan M. Shokat
Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California, United States of America
Chao Zhang, Kevan M. Shokat
Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: jallepap@mskcc.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: MB MBY PVJ. Performed the experiments: MB JM VR-B DL KC. Analyzed the data: MB JM VR-B DL KC PVJ. Contributed reagents/materials/analysis tools: MR CZ KMS SC. Wrote the paper: PVJ.