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Research Article

Abl Kinase Inhibits the Engulfment of Apopotic Cells in Caenorhabditis elegans

  • Michael E Hurwitz,

    Affiliations: Howard Hughes Medical Institute (HHMI), Department of Biology, MIT, Cambridge, Massachusetts, United States of America, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States of America

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  • Pamela J Vanderzalm,

    Affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America

    ¤a Current address: Department Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois, United States of America

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  • Laird Bloom,

    Affiliation: Howard Hughes Medical Institute (HHMI), Department of Biology, MIT, Cambridge, Massachusetts, United States of America

    ¤b Current address: Wyeth Pharmaceuticals, Biological Technologies Department, Cambridge, Massachusetts, United States of America

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  • Julia Goldman,

    Affiliation: Howard Hughes Medical Institute (HHMI), Department of Biology, MIT, Cambridge, Massachusetts, United States of America

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  • Gian Garriga,

    Affiliations: Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America, Helen Wills Neuroscience Institute, University of California, Berkeley, California, United States of America

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  • H. Robert Horvitz mail

    To whom correspondence should be addressed. E-mail: horvitz@mit.edu

    Affiliation: Howard Hughes Medical Institute (HHMI), Department of Biology, MIT, Cambridge, Massachusetts, United States of America

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  • Published: April 28, 2009
  • DOI: 10.1371/journal.pbio.1000099

About the Authors

Michael E Hurwitz, Laird Bloom, Julia Goldman, H. Robert Horvitz
Howard Hughes Medical Institute (HHMI), Department of Biology, MIT, Cambridge, Massachusetts, United States of America
Michael E Hurwitz
Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States of America
Pamela J Vanderzalm, Gian Garriga
Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America
Gian Garriga
Helen Wills Neuroscience Institute, University of California, Berkeley, California, United States of America

Corresponding Author

Email: horvitz@mit.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MEH, PJV, LB, GG, and HRH conceived and designed the experiments. MEH, PJV, LB, and JG performed the experiments. MEH, PJV, LB, GG, and HRH analyzed the data. MEH, PJV, GG, and HRH wrote the paper.