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Research Article

Base Excision by Thymine DNA Glycosylase Mediates DNA-Directed Cytotoxicity of 5-Fluorouracil

  • Christophe Kunz,

    Affiliation: Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland

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  • Frauke Focke,

    Affiliation: Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland

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  • Yusuke Saito,

    Affiliation: Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland

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  • David Schuermann,

    Affiliation: Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland

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  • Teresa Lettieri,

    Affiliation: Institute of Cell Biology, ETH Zürich, Zürich, Switzerland

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  • Jim Selfridge,

    Affiliation: Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh, Scotland

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  • Primo Schär mail

    To whom correspondence should be addressed. E-mail: primo.schaer@unibas.ch

    Affiliation: Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland

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  • Published: April 28, 2009
  • DOI: 10.1371/journal.pbio.1000091

About the Authors

Christophe Kunz, Frauke Focke, Yusuke Saito, David Schuermann, Primo Schär
Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
Teresa Lettieri
Institute of Cell Biology, ETH Zürich, Zürich, Switzerland
Jim Selfridge
Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh, Scotland

Corresponding Author

Email: primo.schaer@unibas.ch

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CK and PS conceived and designed the experiments. CK and FF performed the experiments. CK and PS analyzed the data. YS, DS, TL, and JS contributed reagents/materials/analysis tools. CK and PS wrote the paper.