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Research Article

Coordinated Movement of Cytoplasmic and Transmembrane Domains of RyR1 upon Gating

  • Montserrat Samsó mail,

    To whom correspondence should be addressed. E-mail: msamso@zeus.bwh.harvard.edu

    Affiliation: Division of Anesthesia Research, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Wei Feng,

    Affiliation: Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California, United States of America

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  • Isaac N Pessah,

    Affiliation: Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California, United States of America

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  • P. D Allen

    Affiliation: Division of Anesthesia Research, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: April 14, 2009
  • DOI: 10.1371/journal.pbio.1000085

About the Authors

Montserrat Samsó, P. D Allen
Division of Anesthesia Research, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Wei Feng, Isaac N Pessah
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California, United States of America

Corresponding Author

Email: msamso@zeus.bwh.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MS collected the cryoEM data and performed image processing,and secondary structure prediction studies; WF performed the lipid bilayer and [3H] binding experiments; MS, WF, INP, and PDA designed the study; MS wrote the manuscript; INP and PDA commented on and edited the manuscript.