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Research Article

Commitment to the Regulatory T Cell Lineage Requires CARMA1 in the Thymus but Not in the Periphery

  • Michael J Barnes mail,

    To whom correspondence should be addressed. E-mail: mbarnes@scripps.edu (MJB); Kasper.Hoebe@cchmc.org (KH)

    Affiliation: Department of Genetics, The Scripps Research Institute, La Jolla, California, United States of America

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  • Philippe Krebs,

    Affiliation: Department of Genetics, The Scripps Research Institute, La Jolla, California, United States of America

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  • Nathaniel Harris,

    Affiliation: Division of Molecular Immunology, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio, United States of America

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  • Celine Eidenschenk,

    Affiliation: Department of Genetics, The Scripps Research Institute, La Jolla, California, United States of America

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  • Rosana Gonzalez-Quintial,

    Affiliation: Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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  • Carrie N Arnold,

    Affiliation: Department of Genetics, The Scripps Research Institute, La Jolla, California, United States of America

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  • Karine Crozat,

    Affiliation: Department of Genetics, The Scripps Research Institute, La Jolla, California, United States of America

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  • Sosathya Sovath,

    Affiliation: Department of Genetics, The Scripps Research Institute, La Jolla, California, United States of America

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  • Eva Marie Moresco,

    Affiliation: Department of Genetics, The Scripps Research Institute, La Jolla, California, United States of America

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  • Argyrios N Theofilopoulos,

    Affiliation: Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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  • Bruce Beutler,

    Affiliation: Department of Genetics, The Scripps Research Institute, La Jolla, California, United States of America

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  • Kasper Hoebe mail

    To whom correspondence should be addressed. E-mail: mbarnes@scripps.edu (MJB); Kasper.Hoebe@cchmc.org (KH)

    Affiliation: Division of Molecular Immunology, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio, United States of America

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  • Published: March 03, 2009
  • DOI: 10.1371/journal.pbio.1000051

About the Authors

Michael J Barnes, Philippe Krebs, Celine Eidenschenk, Carrie N Arnold, Karine Crozat, Sosathya Sovath, Eva Marie Moresco, Bruce Beutler
Department of Genetics, The Scripps Research Institute, La Jolla, California, United States of America
Nathaniel Harris, Kasper Hoebe
Division of Molecular Immunology, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio, United States of America
Rosana Gonzalez-Quintial, Argyrios N Theofilopoulos
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MJB and KH conceived and designed the experiments. MJB, PK, NH, CE, RGQ, CNA, and KC performed the experiments. MJB, SS, EMM, ANT, BB, and KH analyzed the data. KC, ANT, and BB contributed reagents/materials/analysis tools. MJB wrote the paper.