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Research Article

Functional Anatomy of Polycomb and Trithorax Chromatin Landscapes in Drosophila Embryos

  • Bernd Schuettengruber equal contributor,

    equal contributor Contributed equally to this work with: Bernd Schuettengruber, Mythily Ganapathi

    Affiliation: Institut de Génétique Humaine, CNRS, Montpellier, France

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  • Mythily Ganapathi equal contributor,

    equal contributor Contributed equally to this work with: Bernd Schuettengruber, Mythily Ganapathi

    Affiliation: Institut de Génétique Humaine, CNRS, Montpellier, France

    ¤ Current address: Department of Molecular Biology & Biochemistry, Rutgers State University of New Jersey, Nelson Laboratories, Piscataway, New Jersey, United States of America

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  • Benjamin Leblanc,

    Affiliation: Institut de Génétique Humaine, CNRS, Montpellier, France

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  • Manuela Portoso,

    Affiliation: Institut de Génétique Humaine, CNRS, Montpellier, France

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  • Rami Jaschek,

    Affiliation: Department of Computer Science and Applied Mathematics, The Weizmann Institute of Science, Rehovot, Israel

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  • Bas Tolhuis,

    Affiliation: Division of Molecular Genetics, and the Centre for Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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  • Maarten van Lohuizen,

    Affiliation: Division of Molecular Genetics, and the Centre for Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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  • Amos Tanay,

    Affiliation: Department of Computer Science and Applied Mathematics, The Weizmann Institute of Science, Rehovot, Israel

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  • Giacomo Cavalli mail

    To whom correspondence should be addressed. E-mail: Giacomo.Cavalli@igh.cnrs.fr

    Affiliation: Institut de Génétique Humaine, CNRS, Montpellier, France

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  • Published: January 13, 2009
  • DOI: 10.1371/journal.pbio.1000013

About the Authors

Bernd Schuettengruber, Mythily Ganapathi, Benjamin Leblanc, Manuela Portoso, Giacomo Cavalli
Institut de Génétique Humaine, CNRS, Montpellier, France
Rami Jaschek, Amos Tanay
Department of Computer Science and Applied Mathematics, The Weizmann Institute of Science, Rehovot, Israel
Bas Tolhuis, Maarten van Lohuizen
Division of Molecular Genetics, and the Centre for Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands

Corresponding Author

Email: Giacomo.Cavalli@igh.cnrs.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

BS, MG, and GC conceived and designed the experiments. BS and MP performed the experiments. BS, MG, BL, RJ, BT, AT, and GC analyzed the data. BS, BL, MP, RJ, BT, MvL, and AT contributed reagents/materials/analysis tools. BS, MG, MP, AT, and GC wrote the paper.