Advertisement
Research Article

The Influence of Catalysis on Mad2 Activation Dynamics

  • Marco Simonetta equal contributor,

    equal contributor Contributed equally to this work with: Marco Simonetta, Romilde Manzoni

    Affiliation: Department of Experimental Oncology, European Institute of Oncology, Milan, Italy

    X
  • Romilde Manzoni equal contributor,

    equal contributor Contributed equally to this work with: Marco Simonetta, Romilde Manzoni

    Affiliation: IFOM, Istituto FIRC di Oncologia Molecolare, Milan, Italy

    X
  • Roberto Mosca,

    Affiliation: IFOM, Istituto FIRC di Oncologia Molecolare, Milan, Italy

    X
  • Marina Mapelli,

    Affiliation: Department of Experimental Oncology, European Institute of Oncology, Milan, Italy

    X
  • Lucia Massimiliano,

    Affiliation: Department of Experimental Oncology, European Institute of Oncology, Milan, Italy

    X
  • Martin Vink,

    Affiliation: Department of Experimental Oncology, European Institute of Oncology, Milan, Italy

    ¤ Current address: New York Structural Biology Center, New York, New York, United States of America

    X
  • Bela Novak,

    Affiliation: Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford, United Kingdom

    X
  • Andrea Musacchio mail,

    To whom correspondence should be addressed. E-mail: andrea.ciliberto@ifom-ieo-campus.it (AC); andrea.musacchio@ifom-ieo-campus.it (AM)

    Affiliations: Department of Experimental Oncology, European Institute of Oncology, Milan, Italy, Research Unit of the Italian Institute of Technology (IIT) Foundation at the IFOM-IEO Campus, Milan, Italy

    X
  • Andrea Ciliberto mail

    To whom correspondence should be addressed. E-mail: andrea.ciliberto@ifom-ieo-campus.it (AC); andrea.musacchio@ifom-ieo-campus.it (AM)

    Affiliation: IFOM, Istituto FIRC di Oncologia Molecolare, Milan, Italy

    X
  • Published: January 13, 2009
  • DOI: 10.1371/journal.pbio.1000010

About the Authors

Marco Simonetta, Marina Mapelli, Lucia Massimiliano, Martin Vink, Andrea Musacchio
Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
Romilde Manzoni, Roberto Mosca, Andrea Ciliberto
IFOM, Istituto FIRC di Oncologia Molecolare, Milan, Italy
Bela Novak
Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford, United Kingdom
Andrea Musacchio
Research Unit of the Italian Institute of Technology (IIT) Foundation at the IFOM-IEO Campus, Milan, Italy

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

M. Simonetta, R. Manzoni, M. Mapelli, M. Vink, A. Musacchio, and A. Ciliberto conceived and designed the experiments. M. Simonetta performed the experiments. M. Simonetta, R. Manzoni, R. Mosca, M. Mapelli, and A. Ciliberto analyzed the data. M. Simonetta, R. Manzoni, R. Mosca, M. Mapelli, L. Massimiliano, B. Novak, contributed reagents/materials/analysis tools. A. Musacchio and A. Ciliberto wrote the paper.