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Research Article

Tissue-Specific Genetic Control of Splicing: Implications for the Study of Complex Traits

  • Erin L Heinzen equal contributor,

    equal contributor Contributed equally to this work with: Erin L Heinzen, Dongliang Ge

    Affiliation: Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina, United States of America

    X
  • Dongliang Ge equal contributor,

    equal contributor Contributed equally to this work with: Erin L Heinzen, Dongliang Ge

    Affiliation: Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina, United States of America

    X
  • Kenneth D Cronin,

    Affiliation: Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina, United States of America

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  • Jessica M Maia,

    Affiliation: Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina, United States of America

    X
  • Kevin V Shianna,

    Affiliation: Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina, United States of America

    X
  • Willow N Gabriel,

    Affiliation: Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina, United States of America

    X
  • Kathleen A Welsh-Bohmer,

    Affiliation: Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, North Carolina, United States of America

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  • Christine M Hulette,

    Affiliation: Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, North Carolina, United States of America

    X
  • Thomas N Denny,

    Affiliation: Human Vaccine Institute, Duke University, Durham, North Carolina, United States of America

    X
  • David B Goldstein mail

    To whom correspondence should be addressed. E-mail: d.goldstein@duke.edu

    Affiliation: Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina, United States of America

    X
  • Published: December 23, 2008
  • DOI: 10.1371/journal.pbio.1000001

About the Authors

Erin L Heinzen, Dongliang Ge, Kenneth D Cronin, Jessica M Maia, Kevin V Shianna, Willow N Gabriel, David B Goldstein
Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina, United States of America
Kathleen A Welsh-Bohmer, Christine M Hulette
Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, North Carolina, United States of America
Thomas N Denny
Human Vaccine Institute, Duke University, Durham, North Carolina, United States of America

Corresponding Author

Email: d.goldstein@duke.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ELH, DG, and DBG conceived and designed the experiments. ELH, KDC, and KVS performed the experiments. ELH, DG, JMM, KVS, and DBG analyzed the data. DG, JMM, WNG, KAW-B, CMH, and TND contributed reagents/materials/analysis tools. ELH wrote the paper.