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Research Article

PKMζ Maintains Spatial, Instrumental, and Classically Conditioned Long-Term Memories

  • Peter Serrano equal contributor,

    equal contributor Contributed equally to this work with: Peter Serrano, Eugenia L Friedman

    Affiliation: Department of Physiology and Pharmacology, The Robert F. Furchgott Center for Neural and Behavioral Science, State University of New York, Brooklyn, New York, United States of America

    ¤ Current address: Department of Psychology and the Gene Research Center, Hunter College, City University of New York, New York, New York, United States of America

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  • Eugenia L Friedman equal contributor,

    equal contributor Contributed equally to this work with: Peter Serrano, Eugenia L Friedman

    Affiliations: Department of Psychiatry, University of Wisconsin-Madison Medical School, Madison, Wisconsin, United States of America, Neuroscience Training Program, University of Wisconsin-Madison Medical School, Madison, Wisconsin, United States of America

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  • Jana Kenney,

    Affiliation: Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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  • Stephen M Taubenfeld,

    Affiliation: Fishberg Department of Neuroscience, Mount Sinai School of Medicine, Icahn Medical Institute, New York, New York, United States of America

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  • Joshua M Zimmerman,

    Affiliation: Neuroscience Program, University of Michigan, Ann Arbor, Michigan, United States of America

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  • John Hanna,

    Affiliation: Department of Physiology and Pharmacology, The Robert F. Furchgott Center for Neural and Behavioral Science, State University of New York, Brooklyn, New York, United States of America

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  • Cristina Alberini,

    Affiliation: Fishberg Department of Neuroscience, Mount Sinai School of Medicine, Icahn Medical Institute, New York, New York, United States of America

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  • Ann E Kelley †,

    † Deceased.

    Affiliation: Department of Psychiatry, University of Wisconsin-Madison Medical School, Madison, Wisconsin, United States of America

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  • Stephen Maren,

    Affiliations: Neuroscience Program, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Psychology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Jerry W Rudy,

    Affiliation: Department of Psychology, Center for Neuroscience, University of Colorado, Boulder, Colorado, United States of America

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  • Jerry C. P Yin,

    Affiliations: Department of Psychiatry, University of Wisconsin-Madison Medical School, Madison, Wisconsin, United States of America, Department of Genetics, University of Wisconsin-Madison Medical School, Madison, Wisconsin, United States of America

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  • Todd C Sacktor mail,

    To whom correspondence should be addressed. E-mail: tsacktor@downstate.edu (TCS); afenton@downstate.edu (AAF)

    Affiliations: Department of Physiology and Pharmacology, The Robert F. Furchgott Center for Neural and Behavioral Science, State University of New York, Brooklyn, New York, United States of America, Department of Neurology, The Robert F. Furchgott Center for Neural and Behavioral Science, State University of New York, Brooklyn, New York, United States of America

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  • André A Fenton mail

    To whom correspondence should be addressed. E-mail: tsacktor@downstate.edu (TCS); afenton@downstate.edu (AAF)

    Affiliation: Department of Physiology and Pharmacology, The Robert F. Furchgott Center for Neural and Behavioral Science, State University of New York, Brooklyn, New York, United States of America

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  • Published: December 23, 2008
  • DOI: 10.1371/journal.pbio.0060318

About the Authors

Peter Serrano, John Hanna, Todd C Sacktor, André A Fenton
Department of Physiology and Pharmacology, The Robert F. Furchgott Center for Neural and Behavioral Science, State University of New York, Brooklyn, New York, United States of America
Eugenia L Friedman, Ann E Kelley, Jerry C. P Yin
Department of Psychiatry, University of Wisconsin-Madison Medical School, Madison, Wisconsin, United States of America
Eugenia L Friedman
Neuroscience Training Program, University of Wisconsin-Madison Medical School, Madison, Wisconsin, United States of America
Jana Kenney
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Stephen M Taubenfeld, Cristina Alberini
Fishberg Department of Neuroscience, Mount Sinai School of Medicine, Icahn Medical Institute, New York, New York, United States of America
Joshua M Zimmerman, Stephen Maren
Neuroscience Program, University of Michigan, Ann Arbor, Michigan, United States of America
Stephen Maren
Department of Psychology, University of Michigan, Ann Arbor, Michigan, United States of America
Jerry W Rudy
Department of Psychology, Center for Neuroscience, University of Colorado, Boulder, Colorado, United States of America
Jerry C. P Yin
Department of Genetics, University of Wisconsin-Madison Medical School, Madison, Wisconsin, United States of America
Todd C Sacktor
Department of Neurology, The Robert F. Furchgott Center for Neural and Behavioral Science, State University of New York, Brooklyn, New York, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

PS, ELF, JK, SMT, and JMZ performed and analyzed the eight-arm radial maze, tone-fear, water maze, inhibitory avoidance, and contextual fear experiments, respectively. JH assisted with the eight-arm radial maze training. JWR performed the dorsal and ventral hippocampi contextual fear experiments. CA, AEK, SM, JWR, JCPY, TCS, and AAF supervised and designed the research. TCS and AAF wrote the manuscript.