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Research Article

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

  • Jean-Philippe Coppé,

    Affiliation: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

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  • Christopher K Patil equal contributor,

    equal contributor Contributed equally to this work with: Christopher K Patil, Francis Rodier

    Affiliation: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

    X
  • Francis Rodier equal contributor,

    equal contributor Contributed equally to this work with: Christopher K Patil, Francis Rodier

    Affiliations: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America, Buck Institute for Age Research, Novato, California, United States of America

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  • Yu Sun,

    Affiliation: Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Denise P Muñoz,

    Affiliations: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America, Buck Institute for Age Research, Novato, California, United States of America

    X
  • Joshua Goldstein,

    Affiliation: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

    ¤ Current address: Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

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  • Peter S Nelson,

    Affiliation: Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Pierre-Yves Desprez,

    Affiliations: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America, California Pacific Medical Center Research Institute, San Francisco, California, United States of America

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  • Judith Campisi mail

    To whom correspondence should be addressed. E-mail: jcampisi@lbl.gov

    Affiliations: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America, Buck Institute for Age Research, Novato, California, United States of America

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  • Published: December 02, 2008
  • DOI: 10.1371/journal.pbio.0060301

About the Authors

Jean-Philippe Coppé, Christopher K Patil, Francis Rodier, Denise P Muñoz, Joshua Goldstein, Pierre-Yves Desprez, Judith Campisi
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
Francis Rodier, Denise P Muñoz, Judith Campisi
Buck Institute for Age Research, Novato, California, United States of America
Yu Sun, Peter S Nelson
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Pierre-Yves Desprez
California Pacific Medical Center Research Institute, San Francisco, California, United States of America

Corresponding Author

Email: jcampisi@lbl.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JPC and CKP carried out and analyzed array experiments. JPC and FR conceived and designed genetic experiments. JPC, JG, and PYD designed and carried out the biological activity experiments. JPC, YS, and PSN designed and carried out the clinical experiments, JPC, DPM and JG designed and carried out the immunofluorescence experiments, JPC analyzed the data, JPC, CKP, FR, PYD, and JC wrote the paper.