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Research Article

Modeling a Snap-Action, Variable-Delay Switch Controlling Extrinsic Cell Death

  • John G Albeck equal contributor,

    equal contributor Contributed equally to this work with: John G Albeck, John M Burke

    Affiliation: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • John M Burke equal contributor,

    equal contributor Contributed equally to this work with: John G Albeck, John M Burke

    Affiliations: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Biological Engineering Department, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Sabrina L Spencer,

    Affiliations: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Computational and Systems Biology Initiative, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Douglas A Lauffenburger,

    Affiliations: Biological Engineering Department, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Computational and Systems Biology Initiative, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Peter K Sorger mail

    To whom correspondence should be addressed. E-mail: peter_sorger@hms.harvard.edu

    Affiliations: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Biological Engineering Department, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Published: December 02, 2008
  • DOI: 10.1371/journal.pbio.0060299

About the Authors

John G Albeck, John M Burke, Sabrina L Spencer, Peter K Sorger
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America
John M Burke, Douglas A Lauffenburger, Peter K Sorger
Biological Engineering Department, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Sabrina L Spencer, Douglas A Lauffenburger
Computational and Systems Biology Initiative, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: peter_sorger@hms.harvard.edu

Competing Interests

PKS is a member of the board of directors of Applied Precision Inc., manufacturer of the microscopes used in this study.

Author Contributions

JGA, JMB, SLS, DAL, and PKS worked closely together to design, perform and interpret the experiments; JGA and PKS wrote the paper.