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Research Article

Gamma-Secretase Represents a Therapeutic Target for the Treatment of Invasive Glioma Mediated by the p75 Neurotrophin Receptor

  • LiMei Wang,

    Affiliations: Department of Oncology, University of Calgary, and Tom Baker Cancer Centre, Calgary, Canada, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada, Clark H. Smith Brain Tumor Center and Southern Alberta Cancer Research Institute, Calgary, Canada

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  • Jennifer J Rahn,

    Affiliations: Department of Oncology, University of Calgary, and Tom Baker Cancer Centre, Calgary, Canada, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada, Clark H. Smith Brain Tumor Center and Southern Alberta Cancer Research Institute, Calgary, Canada

    X
  • XueQing Lun,

    Affiliations: Department of Oncology, University of Calgary, and Tom Baker Cancer Centre, Calgary, Canada, Clark H. Smith Brain Tumor Center and Southern Alberta Cancer Research Institute, Calgary, Canada

    X
  • Beichen Sun,

    Affiliations: Department of Oncology, University of Calgary, and Tom Baker Cancer Centre, Calgary, Canada, Clark H. Smith Brain Tumor Center and Southern Alberta Cancer Research Institute, Calgary, Canada

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  • John J. P Kelly,

    Affiliations: Department of Cell Biology and Anatomy, University of Calgary, Calgary, Canada, Hotchkiss Brain Institute, Calgary, Canada

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  • Samuel Weiss,

    Affiliations: Department of Cell Biology and Anatomy, University of Calgary, Calgary, Canada, Hotchkiss Brain Institute, Calgary, Canada

    X
  • Stephen M Robbins,

    Affiliations: Department of Oncology, University of Calgary, and Tom Baker Cancer Centre, Calgary, Canada, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada, Clark H. Smith Brain Tumor Center and Southern Alberta Cancer Research Institute, Calgary, Canada

    X
  • Peter A Forsyth equal contributor mail,

    equal contributor Contributed equally to this work with: Peter A Forsyth, Donna L Senger

    To whom correspondence should be addressed. E-mail: pforsyth@ucalgary.ca (PAF); senger@ucalgary.ca (DLS)

    Affiliations: Department of Oncology, University of Calgary, and Tom Baker Cancer Centre, Calgary, Canada, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada, Clark H. Smith Brain Tumor Center and Southern Alberta Cancer Research Institute, Calgary, Canada, Department of Clinical Neurosciences, University of Calgary, Calgary, Canada

    X
  • Donna L Senger equal contributor mail

    equal contributor Contributed equally to this work with: Peter A Forsyth, Donna L Senger

    To whom correspondence should be addressed. E-mail: pforsyth@ucalgary.ca (PAF); senger@ucalgary.ca (DLS)

    Affiliations: Department of Oncology, University of Calgary, and Tom Baker Cancer Centre, Calgary, Canada, Clark H. Smith Brain Tumor Center and Southern Alberta Cancer Research Institute, Calgary, Canada

    X
  • Published: November 25, 2008
  • DOI: 10.1371/journal.pbio.0060289

About the Authors

LiMei Wang, Jennifer J Rahn, XueQing Lun, Beichen Sun, Stephen M Robbins, Peter A Forsyth, Donna L Senger
Department of Oncology, University of Calgary, and Tom Baker Cancer Centre, Calgary, Canada
LiMei Wang, Jennifer J Rahn, Stephen M Robbins, Peter A Forsyth
Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada
LiMei Wang, Jennifer J Rahn, XueQing Lun, Beichen Sun, Stephen M Robbins, Peter A Forsyth, Donna L Senger
Clark H. Smith Brain Tumor Center and Southern Alberta Cancer Research Institute, Calgary, Canada
John J. P Kelly, Samuel Weiss
Department of Cell Biology and Anatomy, University of Calgary, Calgary, Canada
John J. P Kelly, Samuel Weiss
Hotchkiss Brain Institute, Calgary, Canada
Peter A Forsyth
Department of Clinical Neurosciences, University of Calgary, Calgary, Canada

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JJR, XL, SMR, PAF, and DLS conceived and designed the experiments. LW, JJR, XL, BS, and JJPK performed the experiments. LW, SMR, PAF, and DLS analyzed the data. JJPK and SW contributed reagents/materials/analysis tools. LW, SMR, and DLS wrote the paper.