Advertisement
Research Article

The Pervasive Effects of an Antibiotic on the Human Gut Microbiota, as Revealed by Deep 16S rRNA Sequencing

  • Les Dethlefsen,

    Affiliations: Department of Microbiology and Immunology, Stanford University, Stanford, California, United States of America, Department of Medicine, Stanford University, Stanford, California, United States of America

    X
  • Sue Huse,

    Affiliation: Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, Massachusetts, United States of America

    X
  • Mitchell L Sogin,

    Affiliation: Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, Massachusetts, United States of America

    X
  • David A Relman mail

    To whom correspondence should be addressed. E-mail: relman@stanford.edu

    Affiliations: Department of Microbiology and Immunology, Stanford University, Stanford, California, United States of America, Department of Medicine, Stanford University, Stanford, California, United States of America, Veterans Affairs Palo Alto Health Care System, Palo Alto, California, United States of America

    X
  • Published: November 18, 2008
  • DOI: 10.1371/journal.pbio.0060280

About the Authors

Les Dethlefsen, David A Relman
Department of Microbiology and Immunology, Stanford University, Stanford, California, United States of America
Les Dethlefsen, David A Relman
Department of Medicine, Stanford University, Stanford, California, United States of America
Sue Huse, Mitchell L Sogin
Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, Massachusetts, United States of America
David A Relman
Veterans Affairs Palo Alto Health Care System, Palo Alto, California, United States of America

Corresponding Author

Email: relman@stanford.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

LD, MLS, and DAR conceived and designed the experiments. LD performed the experiments. LD, SMH, MLS, and DAR analyzed the data. LD, SMH, MLS, and DAR contributed reagents/materials/analysis tools. LD and DAR wrote the paper.