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Research Article

SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum

  • Kèvin Knoops,

    Affiliations: Section Electron Microscopy, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands, Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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  • Marjolein Kikkert,

    Affiliation: Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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  • Sjoerd H. E. van den Worm,

    Affiliation: Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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  • Jessika C Zevenhoven-Dobbe,

    Affiliation: Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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  • Yvonne van der Meer,

    Affiliation: Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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  • Abraham J Koster,

    Affiliation: Section Electron Microscopy, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands

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  • A. Mieke Mommaas,

    Affiliation: Section Electron Microscopy, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands

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  • Eric J Snijder mail

    To whom correspondence should be addressed. E-mail: e.j.snijder@lumc.nl

    Affiliation: Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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  • Published: September 16, 2008
  • DOI: 10.1371/journal.pbio.0060226

About the Authors

Kèvin Knoops, Abraham J Koster, A. Mieke Mommaas
Section Electron Microscopy, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
Kèvin Knoops, Marjolein Kikkert, Sjoerd H. E. van den Worm, Jessika C Zevenhoven-Dobbe, Yvonne van der Meer, Eric J Snijder
Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

Corresponding Author

Email: e.j.snijder@lumc.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KK, MK, SHEvdW, JCZD, YvdM, AJK, AMM, and EJS conceived and designed the experiments. KK, SHEvdW, JCZD, YvdM, and EJS performed the experiments. KK, MK, SHEvdW, YvdM, AJK, AMM, and EJS analyzed the data. SHEvdW, JCZD, AJK, and AMM contributed reagents/materials/analysis tools. KK, MK, and EJS wrote the paper.