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Research Article

Direct Estimation of the Mitochondrial DNA Mutation Rate in Drosophila melanogaster

  • Cathy Haag-Liautard,

    Affiliation: Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom

    ¤ Current address: University of Fribourg, Institute of Ecology and Evolution, Fribourg, Switzerland

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  • Nicole Coffey,

    Affiliation: Department of Biology, Indiana University, Bloomington, Indiana, United States of America

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  • David Houle,

    Affiliation: Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America

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  • Michael Lynch,

    Affiliation: Department of Biology, Indiana University, Bloomington, Indiana, United States of America

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  • Brian Charlesworth,

    Affiliation: Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom

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  • Peter D Keightley mail

    To whom correspondence should be addressed. E-mail: keightley.pb2008@gmail.com

    Affiliation: Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom

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  • Published: August 19, 2008
  • DOI: 10.1371/journal.pbio.0060204

About the Authors

Cathy Haag-Liautard, Brian Charlesworth, Peter D Keightley
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
Nicole Coffey, Michael Lynch
Department of Biology, Indiana University, Bloomington, Indiana, United States of America
David Houle
Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America

Corresponding Author

Email: keightley.pb2008@gmail.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

DH was responsible for producing the Florida MA lines CH-L carried out the DHPLC analysis of MA lines, associated DNA sequencing, and pyrosequencing. NC and ML were responsible the direct sequencing of MA lines. PDK and CH-L analysed the data, with advice from BC. PDK drafted the paper. All authors revised the manuscript.