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Research Article

TSCOT + Thymic Epithelial Cell-Mediated Sensitive CD4 Tolerance by Direct Presentation

  • Sejin Ahn equal contributor,

    equal contributor Contributed equally to this work with: Sejin Ahn, Gwanghee Lee, Soo Jung Yang, Deokjae Lee

    Affiliation: Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America

    ¤a Current address: Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Gwanghee Lee equal contributor,

    equal contributor Contributed equally to this work with: Sejin Ahn, Gwanghee Lee, Soo Jung Yang, Deokjae Lee

    Affiliation: Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America

    ¤b Current address: Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Soo Jung Yang equal contributor,

    equal contributor Contributed equally to this work with: Sejin Ahn, Gwanghee Lee, Soo Jung Yang, Deokjae Lee

    Affiliation: Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America

    ¤c Current address: Division of Biological Sciences, Seoul National University, Seoul, Korea

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  • Deokjae Lee equal contributor,

    equal contributor Contributed equally to this work with: Sejin Ahn, Gwanghee Lee, Soo Jung Yang, Deokjae Lee

    Affiliation: Research Center for Molecular and Cellular Biology, Inha University, Incheon, Korea

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  • Seunghyuk Lee,

    Affiliation: Department of Biological Sciences, Inha University, Incheon, Korea

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  • Hyo Sun Shin,

    Affiliation: Department of Biological Sciences, Inha University, Incheon, Korea

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  • Min Cheol Kim,

    Affiliation: Department of Biological Sciences, Inha University, Incheon, Korea

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  • Kee Nyung Lee,

    Affiliation: Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America

    ¤d Current address: Laboratory of Immunology, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, Korea

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  • Douglas C Palmer,

    Affiliation: National Institute of Cancer, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Marc R Theoret,

    Affiliation: National Institute of Cancer, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Eric J Jenkinson,

    Affiliation: Medical Research Council (MRC) Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, United Kingdom

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  • Graham Anderson,

    Affiliation: Medical Research Council (MRC) Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, United Kingdom

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  • Nicholas P Restifo,

    Affiliation: National Institute of Cancer, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Moon Gyo Kim mail

    To whom correspondence should be addressed. E-mail: mgkim@inha.ac.kr

    Affiliations: Research Center for Molecular and Cellular Biology, Inha University, Incheon, Korea, Department of Biological Sciences, Inha University, Incheon, Korea

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  • Published: August 05, 2008
  • DOI: 10.1371/journal.pbio.0060191

About the Authors

Sejin Ahn, Gwanghee Lee, Soo Jung Yang, Kee Nyung Lee
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America
Deokjae Lee, Moon Gyo Kim
Research Center for Molecular and Cellular Biology, Inha University, Incheon, Korea
Seunghyuk Lee, Hyo Sun Shin, Min Cheol Kim, Moon Gyo Kim
Department of Biological Sciences, Inha University, Incheon, Korea
Douglas C Palmer, Marc R Theoret, Nicholas P Restifo
National Institute of Cancer, National Institutes of Health, Bethesda, Maryland, United States of America
Eric J Jenkinson, Graham Anderson
Medical Research Council (MRC) Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, United Kingdom

Corresponding Author

Email: mgkim@inha.ac.kr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MGK conceived and designed the experiments. SA, GL, SJY, DL, HSS, MCK, and MGK performed the experiments. SA, GL, SJY, DL, SL, HSS, MCK, EJJ, GA, and MGK analyzed the data. KNL, DCP, MRT, EJJ, GA, NPR, and MGK contributed reagents/materials/analysis tools. SA, GL, SJY, DL, SL, DCP, GA, NPR, and MGK wrote the paper.