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Research Article

Human and Drosophila Cryptochromes Are Light Activated by Flavin Photoreduction in Living Cells

  • Nathalie Hoang,

    Affiliation: Université Paris VI, UMR-CNRS 7632, Paris, France

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  • Erik Schleicher,

    Affiliation: Freie Universität Berlin, Fachbereich Physik, Berlin, Germany

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  • Sylwia Kacprzak,

    Affiliation: Freie Universität Berlin, Fachbereich Physik, Berlin, Germany

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  • Jean-Pierre Bouly,

    Affiliation: Université Paris VI, UMR-CNRS 7632, Paris, France

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  • Marie Picot,

    Affiliation: Institut de Neurobiologie Alfred Fessard, CNRS UPR 2216 (NGI), Gif-sur-Yvette, France

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  • William Wu,

    Affiliation: Université Paris VI, UMR-CNRS 7632, Paris, France

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  • Albrecht Berndt,

    Affiliation: Department of Structural Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany

    ¤ Current address: MRC, Laboratory of Molecular Biology, Cambridge, United Kingdom

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  • Eva Wolf,

    Affiliation: Department of Structural Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany

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  • Robert Bittl,

    Affiliation: Freie Universität Berlin, Fachbereich Physik, Berlin, Germany

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  • Margaret Ahmad mail

    To whom correspondence should be addressed. E-mail: ahmad@ccr.jussieu.fr

    Affiliations: Université Paris VI, UMR-CNRS 7632, Paris, France, Penn State University, Media, Pennsylvania, United States of America

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  • Published: July 01, 2008
  • DOI: 10.1371/journal.pbio.0060160

About the Authors

Nathalie Hoang, Jean-Pierre Bouly, William Wu, Margaret Ahmad
Université Paris VI, UMR-CNRS 7632, Paris, France
Erik Schleicher, Sylwia Kacprzak, Robert Bittl
Freie Universität Berlin, Fachbereich Physik, Berlin, Germany
Marie Picot
Institut de Neurobiologie Alfred Fessard, CNRS UPR 2216 (NGI), Gif-sur-Yvette, France
Albrecht Berndt, Eva Wolf
Department of Structural Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany
Margaret Ahmad
Penn State University, Media, Pennsylvania, United States of America

Corresponding Author

Email: ahmad@ccr.jussieu.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

NH, ES, SK, RB, and MA conceived and designed the experiments. NH, ES, SK, JPB, WW, and MA performed the experiments. NH, ES, SK, JPB, RB, and MA analyzed the data. MP, AB, and EW contributed reagents/materials/analysis tools. MA wrote the paper.