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Research Article

Bcl-XL Inhibits Membrane Permeabilization by Competing with Bax

  • Lieven P Billen,

    Affiliation: Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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  • Candis L Kokoski,

    Affiliation: Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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  • Jonathan F Lovell,

    Affiliation: Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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  • Brian Leber,

    Affiliations: Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada, Department of Medicine, McMaster University, Hamilton, Ontario, Canada

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  • David W Andrews mail

    To whom correspondence should be addressed. E-mail: andrewsd@mcmaster.ca

    Affiliation: Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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  • Published: June 10, 2008
  • DOI: 10.1371/journal.pbio.0060147

About the Authors

Lieven P Billen, Candis L Kokoski, Jonathan F Lovell, Brian Leber, David W Andrews
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
Brian Leber
Department of Medicine, McMaster University, Hamilton, Ontario, Canada

Corresponding Author

Email: andrewsd@mcmaster.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

LPB, BL, and DWA conceived the experiments and wrote the paper. LPB, CLK, and JFL performed the experiments. All authors analyzed the data.