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Research Article

Selective Ligand Recognition by a Diversity-Generating Retroelement Variable Protein

  • Jason L Miller,

    Affiliation: Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America

    ¤a Current address: Promega Corporation, Madison, Wisconsin, United States of America

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  • Johanne Le Coq,

    Affiliation: Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America

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  • Asher Hodes,

    Affiliations: Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America, The Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America

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  • Roman Barbalat,

    Affiliations: Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America, The Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America

    ¤b Current address: Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America

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  • Jeff F Miller,

    Affiliations: Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America, The Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America

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  • Partho Ghosh mail

    To whom correspondence should be addressed. E-mail: pghosh@ucsd.edu

    Affiliations: Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America, Section of Molecular Biology, University of California San Diego, La Jolla, California, United States of America

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  • Published: June 03, 2008
  • DOI: 10.1371/journal.pbio.0060131

About the Authors

Jason L Miller, Johanne Le Coq, Partho Ghosh
Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America
Asher Hodes, Roman Barbalat, Jeff F Miller
Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America
Asher Hodes, Roman Barbalat, Jeff F Miller
The Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America
Partho Ghosh
Section of Molecular Biology, University of California San Diego, La Jolla, California, United States of America

Corresponding Author

Email: pghosh@ucsd.edu

Competing Interests

JFM is a board member of and both JFM and PG have served as consultants for AvidBiotics Corp. and have received compensation for these services. Under an agreement between AvidBiotics Corp. and University of California San Diego, JLM and PG are entitled to inventors' share of licensing revenue received by the University of California San Diego from AvidBiotics Corp.

Author Contributions

PG and JFM conceived and designed the experiments. JLM, JLC, AC, and RB performed the experiments. JLM, JLC, AC, RB, JFM, and PG analyzed the data. PG wrote the paper.