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Research Article

Notch-Deficient Skin Induces a Lethal Systemic B-Lymphoproliferative Disorder by Secreting TSLP, a Sentinel for Epidermal Integrity

  • Shadmehr Demehri mail,

    To whom correspondence should be addressed. E-mail: Kopan@wustl.edu (RK); demehris@msnotes.wustl.edu (SD)

    Affiliations: Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Zhenyi Liu,

    Affiliation: Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Jonghyeob Lee,

    Affiliation: Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America

    ¤ Current address: Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Meei-Hua Lin,

    Affiliation: Renal Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Seth D Crosby,

    Affiliation: Genome Sequencing Center, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Christopher J Roberts,

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

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  • Perry W Grigsby,

    Affiliation: Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Jeffrey H Miner,

    Affiliation: Renal Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Andrew G Farr,

    Affiliation: Department of Biological Structure and Department of Immunology, University of Washington, Seattle, Washington, United States of America

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  • Raphael Kopan mail

    To whom correspondence should be addressed. E-mail: Kopan@wustl.edu (RK); demehris@msnotes.wustl.edu (SD)

    Affiliations: Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Published: May 27, 2008
  • DOI: 10.1371/journal.pbio.0060123

About the Authors

Shadmehr Demehri, Zhenyi Liu, Jonghyeob Lee, Raphael Kopan
Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Shadmehr Demehri, Raphael Kopan
Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Meei-Hua Lin, Jeffrey H Miner
Renal Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
Seth D Crosby
Genome Sequencing Center, Washington University School of Medicine, St. Louis, Missouri, United States of America
Christopher J Roberts
Rosetta Inpharmatics, Seattle, Washington, United States of America
Perry W Grigsby
Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Andrew G Farr
Department of Biological Structure and Department of Immunology, University of Washington, Seattle, Washington, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

SD conceived and performed most of the experiments. SD and RK designed the experiments, analyzed the data, and wrote the paper. ZL contributed experimental data. JL, SDC, and CJR contributed to microarray analysis. MHL and JHM contributed wrfr–/– samples and microarray data. AGF contributed K14-TSLPtg mice. PWG helped with focal irradiation experiments with specialized equipment he developed.