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Research Article

Topography of Thalamic Projections Requires Attractive and Repulsive Functions of Netrin-1 in the Ventral Telencephalon

  • Ashton W Powell,

    Affiliations: Neuroscience Center, Department of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America, Curriculum in Neuroscience, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Takayuki Sassa,

    Affiliation: Neuroscience Center, Department of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Yongqin Wu,

    Affiliation: Neuroscience Center, Department of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Marc Tessier-Lavigne,

    Affiliation: Genentech, South San Francisco, California, United States of America

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  • Franck Polleux mail

    To whom correspondence should be addressed. E-mail: polleux@med.unc.edu

    Affiliation: Neuroscience Center, Department of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Published: May 13, 2008
  • DOI: 10.1371/journal.pbio.0060116

About the Authors

Ashton W Powell, Takayuki Sassa, Yongqin Wu, Franck Polleux
Neuroscience Center, Department of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America
Ashton W Powell
Curriculum in Neuroscience, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America
Marc Tessier-Lavigne
Genentech, South San Francisco, California, United States of America

Corresponding Author

Email: polleux@med.unc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AP performed the experiments, analyzed the data presented in all figures except those indicated below, and wrote the paper with FP. TS performed the experiments and analyzed the data presented in Figures 10 and S12. TS provided feedback on the manuscript. YW performed all the in situ hybridization experiments. MTL provided key reagents. FP conceived and designed the experiments, as well as performed the data analysis. FP supervised AP, TS, and YW, and wrote the manuscript with AP.