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Research Article

A Competition between Stimulators and Antagonists of Upf Complex Recruitment Governs Human Nonsense-Mediated mRNA Decay

  • Guramrit Singh,

    Affiliation: Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, United States of America

    ¤ Current address: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Indrani Rebbapragada,

    Affiliation: Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, United States of America

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  • Jens Lykke-Andersen mail

    To whom correspondence should be addressed. E-mail: Jens.Lykke-Andersen@colorado.edu

    Affiliation: Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, United States of America

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  • Published: April 29, 2008
  • DOI: 10.1371/journal.pbio.0060111

About the Authors

Guramrit Singh, Indrani Rebbapragada, Jens Lykke-Andersen
Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, United States of America

Corresponding Author

Email: Jens.Lykke-Andersen@colorado.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

GS, IR, and JL-A conceived and designed the experiments. GS and IR performed the experiments. GS, IR, and JL-A analyzed the data. GS and IR contributed reagents/materials/analysis tools. GS and JL-A wrote the paper.