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Research Article

Genetic and Physiologic Dissection of the Vertebrate Cardiac Conduction System

  • Neil C Chi mail,

    To whom correspondence should be addressed. E-mail: Neil.Chi@ucsf.edu (NCC); didier_stainier@biochem.ucsf.edu (DYRS)

    Affiliations: Department of Biochemistry and Biophysics and Programs in Developmental Biology, Genetics, and Human Genetics, University of California San Francisco, San Francisco, California, United States of America, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Robin M Shaw,

    Affiliations: Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America, Department of Physiology, University of California San Francisco, San Francisco, California, United States of America, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, United States of America

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  • Benno Jungblut,

    Affiliation: Department of Biochemistry and Biophysics and Programs in Developmental Biology, Genetics, and Human Genetics, University of California San Francisco, San Francisco, California, United States of America

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  • Jan Huisken,

    Affiliation: Department of Biochemistry and Biophysics and Programs in Developmental Biology, Genetics, and Human Genetics, University of California San Francisco, San Francisco, California, United States of America

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  • Tania Ferrer,

    Affiliations: Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States of America, Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States of America

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  • Rima Arnaout,

    Affiliations: Department of Biochemistry and Biophysics and Programs in Developmental Biology, Genetics, and Human Genetics, University of California San Francisco, San Francisco, California, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Ian Scott,

    Affiliation: Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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  • Dimitris Beis,

    Affiliation: Developmental Biology, Biomedical Research Foundation, Academy of Athens, Athens, Greece

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  • Tong Xiao,

    Affiliations: Department of Physiology, University of California San Francisco, San Francisco, California, United States of America, Programs in Neuroscience, Genetics, Human Genetics, and Developmental Biology, University of California San Francisco, San Francisco, California, United States of America

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  • Herwig Baier,

    Affiliations: Department of Physiology, University of California San Francisco, San Francisco, California, United States of America, Programs in Neuroscience, Genetics, Human Genetics, and Developmental Biology, University of California San Francisco, San Francisco, California, United States of America

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  • Lily Y Jan,

    Affiliations: Department of Biochemistry and Biophysics and Programs in Developmental Biology, Genetics, and Human Genetics, University of California San Francisco, San Francisco, California, United States of America, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America, Department of Physiology, University of California San Francisco, San Francisco, California, United States of America, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, United States of America

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  • Martin Tristani-Firouzi,

    Affiliations: Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Didier Y. R Stainier mail

    To whom correspondence should be addressed. E-mail: Neil.Chi@ucsf.edu (NCC); didier_stainier@biochem.ucsf.edu (DYRS)

    Affiliations: Department of Biochemistry and Biophysics and Programs in Developmental Biology, Genetics, and Human Genetics, University of California San Francisco, San Francisco, California, United States of America, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America

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  • Published: May 13, 2008
  • DOI: 10.1371/journal.pbio.0060109

About the Authors

Neil C Chi, Benno Jungblut, Jan Huisken, Rima Arnaout, Lily Y Jan, Didier Y. R Stainier
Department of Biochemistry and Biophysics and Programs in Developmental Biology, Genetics, and Human Genetics, University of California San Francisco, San Francisco, California, United States of America
Neil C Chi, Robin M Shaw, Lily Y Jan, Didier Y. R Stainier
Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America
Neil C Chi, Robin M Shaw
Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
Robin M Shaw, Tong Xiao, Herwig Baier, Lily Y Jan
Department of Physiology, University of California San Francisco, San Francisco, California, United States of America
Robin M Shaw, Lily Y Jan
Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, United States of America
Tania Ferrer, Martin Tristani-Firouzi
Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States of America
Tania Ferrer
Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States of America
Rima Arnaout, Martin Tristani-Firouzi
Harvard Medical School, Boston, Massachusetts, United States of America
Ian Scott
Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
Dimitris Beis
Developmental Biology, Biomedical Research Foundation, Academy of Athens, Athens, Greece
Tong Xiao, Herwig Baier
Programs in Neuroscience, Genetics, Human Genetics, and Developmental Biology, University of California San Francisco, San Francisco, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

NCC, RMS, BJ, JH,, HB, LYJ, MT-F and DYRS conceived and designed the experiments. NCC, RMS, BJ, JH, TF, IS, DB, TX and MT-F performed the experiments. All authors analyzed the data. NCC, RMS, BJ, JH, RA, TA, IS, DB, TX, HB, LYJ, MT-F contributed reagents/materials/analysis tools. NCC, RMS, JH, TF, RA, IS, DB, MT-F, and DYRS wrote the paper.