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Research Article

A Novel CpG Island Set Identifies Tissue-Specific Methylation at Developmental Gene Loci

  • Robert Illingworth,

    Affiliation: Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom

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  • Alastair Kerr,

    Affiliation: Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom

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  • Dina DeSousa,

    Affiliation: Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom

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  • Helle Jørgensen,

    Affiliation: Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, London, United Kingdom

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  • Peter Ellis,

    Affiliation: Wellcome Trust Sanger Centre, Hinxton, Cambridge, United Kingdom

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  • Jim Stalker,

    Affiliation: Wellcome Trust Sanger Centre, Hinxton, Cambridge, United Kingdom

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  • David Jackson,

    Affiliation: Wellcome Trust Sanger Centre, Hinxton, Cambridge, United Kingdom

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  • Chris Clee,

    Affiliation: Wellcome Trust Sanger Centre, Hinxton, Cambridge, United Kingdom

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  • Robert Plumb,

    Affiliation: Wellcome Trust Sanger Centre, Hinxton, Cambridge, United Kingdom

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  • Jane Rogers,

    Affiliation: Wellcome Trust Sanger Centre, Hinxton, Cambridge, United Kingdom

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  • Sean Humphray,

    Affiliation: Wellcome Trust Sanger Centre, Hinxton, Cambridge, United Kingdom

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  • Tony Cox,

    Affiliation: Wellcome Trust Sanger Centre, Hinxton, Cambridge, United Kingdom

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  • Cordelia Langford,

    Affiliation: Wellcome Trust Sanger Centre, Hinxton, Cambridge, United Kingdom

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  • Adrian Bird mail

    To whom correspondence should be addressed. E-mail: a.bird@ed.ac.uk

    Affiliation: Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom

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  • Published: January 29, 2008
  • DOI: 10.1371/journal.pbio.0060022

About the Authors

Robert Illingworth, Alastair Kerr, Dina DeSousa, Adrian Bird
Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
Helle Jørgensen
Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, London, United Kingdom
Peter Ellis, Jim Stalker, David Jackson, Chris Clee, Robert Plumb, Jane Rogers, Sean Humphray, Tony Cox, Cordelia Langford
Wellcome Trust Sanger Centre, Hinxton, Cambridge, United Kingdom

Corresponding Author

Email: a.bird@ed.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AB, RI, and HJ conceived and designed the experiments. RI and DD performed the experiments. RI, AK, JS, DJ, and TC analyzed the data. HJ contributed reagents/materials/analysis tools. PE, SH, and CL designed and printed the CGI microarrays. CC, RP, and JR performed DNA sequencing of the CGI library. RI and AB wrote the paper.