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Research Article

A Mechanism Regulating the Onset of Sox2 Expression in the Embryonic Neural Plate

  • Costis Papanayotou,

    Affiliation: Department of Anatomy & Developmental Biology, University College London, London, United Kingdom

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  • Anne Mey,

    Affiliations: Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Lyon, France, Ecole Normale Supérieure de Lyon, CNRS/INRA, Lyon, France

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  • Anne-Marie Birot,

    Affiliations: Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Lyon, France, Ecole Normale Supérieure de Lyon, CNRS/INRA, Lyon, France

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  • Yasushi Saka,

    Affiliation: Wellcome/Cancer Research UK Gurdon Institute for Cancer and Developmental Biology, Cambridge, United Kingdom

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  • Sharon Boast,

    Affiliation: Department of Anatomy & Developmental Biology, University College London, London, United Kingdom

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  • Jim C Smith,

    Affiliation: Wellcome/Cancer Research UK Gurdon Institute for Cancer and Developmental Biology, Cambridge, United Kingdom

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  • Jacques Samarut,

    Affiliations: Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Lyon, France, Ecole Normale Supérieure de Lyon, CNRS/INRA, Lyon, France

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  • Claudio D Stern mail

    To whom correspondence should be addressed. E-mail: c.stern@ucl.ac.uk

    Affiliation: Department of Anatomy & Developmental Biology, University College London, London, United Kingdom

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  • Published: January 08, 2008
  • DOI: 10.1371/journal.pbio.0060002

About the Authors

Costis Papanayotou, Sharon Boast, Claudio D Stern
Department of Anatomy & Developmental Biology, University College London, London, United Kingdom
Anne Mey, Anne-Marie Birot, Jacques Samarut
Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Lyon, France
Anne Mey, Anne-Marie Birot, Jacques Samarut
Ecole Normale Supérieure de Lyon, CNRS/INRA, Lyon, France
Yasushi Saka, Jim C Smith
Wellcome/Cancer Research UK Gurdon Institute for Cancer and Developmental Biology, Cambridge, United Kingdom

Corresponding Author

Email: c.stern@ucl.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CP and CDS conceived and designed the project and most of the experiments. CP performed most of the experiments. AM and AMB performed the experiments on cES cells and two-hybrid screens from cES cell cDNAs (these were conceived and designed by JS), and CP and SB designed and performed the two-hybrid screen experiments using chicken embryo cDNAs. YS and JCS perfected the use of Venus for BiFCO experiments. AM, AMB, YS, JCS, and JS contributed reagents/materials/analysis tools. CP and CDS wrote the paper.