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Research Article

Transglutaminase 2 Undergoes a Large Conformational Change upon Activation

  • Daniel M Pinkas,

    Affiliation: Department of Chemical Engineering, Stanford University, Stanford, California, United States of America

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  • Pavel Strop,

    Affiliations: Howard Hughes Medical Institute, Stanford University, Stanford, California, United States of America, Department of Molecular and Cellular Physiology, Stanford University, Stanford, California, United States of America, Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, United States of America, Department of Structural Biology, Stanford University, Stanford, California, United States of America, Department of Photon Science, Stanford University, Stanford, California, United States of America

    X
  • Axel T Brunger,

    Affiliations: Howard Hughes Medical Institute, Stanford University, Stanford, California, United States of America, Department of Molecular and Cellular Physiology, Stanford University, Stanford, California, United States of America, Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, United States of America, Department of Structural Biology, Stanford University, Stanford, California, United States of America, Department of Photon Science, Stanford University, Stanford, California, United States of America

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  • Chaitan Khosla mail

    To whom correspondence should be addressed. E-mail: khosla@stanford.edu.

    Affiliations: Department of Chemical Engineering, Stanford University, Stanford, California, United States of America, Department of Chemistry, Stanford University, Stanford, California, United States of America, Department of Biochemistry, Stanford University, Stanford, California, United States of America

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  • Published: December 18, 2007
  • DOI: 10.1371/journal.pbio.0050327

About the Authors

Daniel M Pinkas, Chaitan Khosla
Department of Chemical Engineering, Stanford University, Stanford, California, United States of America
Pavel Strop, Axel T Brunger
Howard Hughes Medical Institute, Stanford University, Stanford, California, United States of America
Pavel Strop, Axel T Brunger
Department of Molecular and Cellular Physiology, Stanford University, Stanford, California, United States of America
Pavel Strop, Axel T Brunger
Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, United States of America
Pavel Strop, Axel T Brunger
Department of Structural Biology, Stanford University, Stanford, California, United States of America
Pavel Strop, Axel T Brunger
Department of Photon Science, Stanford University, Stanford, California, United States of America
Chaitan Khosla
Department of Chemistry, Stanford University, Stanford, California, United States of America
Chaitan Khosla
Department of Biochemistry, Stanford University, Stanford, California, United States of America

Corresponding Author

Email: khosla@stanford.edu.

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

DMP, PS, and CK conceived and designed the experiments. DMP and PS performed the experiments. DMP, PS, ATB, and CK analyzed the data. DMP, PS, and CK wrote the paper.