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Research Article

Novel Roles of Formin mDia2 in Lamellipodia and Filopodia Formation in Motile Cells

  • Changsong Yang,

    Affiliation: Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Lubov Czech,

    Affiliation: Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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  • Silke Gerboth,

    Affiliations: The Italian Foundation for Cancer Research (FIRC) Institute for Molecular Oncology, Milan, Italy, Department of Experimental Oncology, European Institute of Oncology, Milan, Italy

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  • Shin-ichiro Kojima,

    Affiliation: Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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  • Giorgio Scita,

    Affiliations: The Italian Foundation for Cancer Research (FIRC) Institute for Molecular Oncology, Milan, Italy, Department of Experimental Oncology, European Institute of Oncology, Milan, Italy

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  • Tatyana Svitkina mail

    To whom correspondence should be addressed. E-mail: svitkina@sas.upenn.edu

    Affiliation: Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Published: November 27, 2007
  • DOI: 10.1371/journal.pbio.0050317

About the Authors

Changsong Yang, Tatyana Svitkina
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Lubov Czech, Shin-ichiro Kojima
Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
Silke Gerboth, Giorgio Scita
The Italian Foundation for Cancer Research (FIRC) Institute for Molecular Oncology, Milan, Italy
Silke Gerboth, Giorgio Scita
Department of Experimental Oncology, European Institute of Oncology, Milan, Italy

Corresponding Author

Email: svitkina@sas.upenn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CY, GS, and TS conceived and designed the experiments. CY, LC, SG, and SK performed the experiments. CY, SG, GS, and TS analyzed the data. CY, SK, and GS contributed reagents/materials/analysis tools. TS wrote the paper.