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Research Article

Coordinate Gene Regulation during Hematopoiesis Is Related to Genomic Organization

  • Steven T Kosak mail,

    To whom correspondence should be addressed. E-mail: skosak@fhcrc.org (STK); markg@fhcrc.org (MG)

    Affiliation: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • David Scalzo,

    Affiliation: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Sam V Alworth,

    Affiliation: SVision, Bellevue, Washington, United States of America

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  • Fusheng Li,

    Affiliation: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Stephanie Palmer,

    Affiliation: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Tariq Enver,

    Affiliation: MRC Molecular Haematology Unit, Oxford University, United Kingdom

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  • James S. J Lee,

    Affiliation: SVision, Bellevue, Washington, United States of America

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  • Mark Groudine mail

    To whom correspondence should be addressed. E-mail: skosak@fhcrc.org (STK); markg@fhcrc.org (MG)

    Affiliations: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Radiation Oncology, University of Washington School of Medicine, Seattle, Washington, United States of America

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  • Published: November 20, 2007
  • DOI: 10.1371/journal.pbio.0050309

About the Authors

Steven T Kosak, David Scalzo, Fusheng Li, Stephanie Palmer, Mark Groudine
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Sam V Alworth, James S. J Lee
SVision, Bellevue, Washington, United States of America
Tariq Enver
MRC Molecular Haematology Unit, Oxford University, United Kingdom
Mark Groudine
Department of Radiation Oncology, University of Washington School of Medicine, Seattle, Washington, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

STK conceived of the project with MG's assistance. STK, DS, and FL performed the bioinformatics analysis. STK, DS, and SP performed the hybridizations, image capture, and image processing for the analysis of chromosome organization. SVA and JSJL—in consultation with STK and DS—programmed and implemented the SVCell application for pattern recognition and image analysis. TE provided assistance in culturing the FDCPmix progenitors and analyzing the microarray data. STK and MG wrote the manuscript.