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Research Article

Conformational Motion of the ABC Transporter MsbA Induced by ATP Hydrolysis

  • Peter P Borbat,

    Affiliation: Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York, United States of America

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  • Kavitha Surendhran,

    Affiliation: Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Marco Bortolus,

    Affiliation: Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Ping Zou,

    Affiliation: Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Jack H Freed,

    Affiliation: Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York, United States of America

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  • Hassane S Mchaourab mail

    To whom correspondence should be addressed. E-mail: Hassane.mchaourab@vanderbilt.edu

    Affiliation: Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Published: October 09, 2007
  • DOI: 10.1371/journal.pbio.0050271

About the Authors

Peter P Borbat, Jack H Freed
Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York, United States of America
Kavitha Surendhran, Marco Bortolus, Ping Zou, Hassane S Mchaourab
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Corresponding Author

Email: Hassane.mchaourab@vanderbilt.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

HSM conceived and designed the experiments. PPB, KS, and MB performed the experiments. PPB, KS, MB, and JHF analyzed the data. PZ contributed reagents/materials/analysis tools. PPB, JHF, and HSM wrote the paper.