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Research Article

MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae

  • Oliver Medvedik equal contributor,

    equal contributor Contributed equally to this work with: Oliver Medvedik, Dudley W Lamming

    Affiliation: Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Dudley W Lamming equal contributor,

    equal contributor Contributed equally to this work with: Oliver Medvedik, Dudley W Lamming

    Affiliation: Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Keyman D Kim,

    Affiliation: Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • David A Sinclair mail

    To whom correspondence should be addressed. E-mail: david_sinclair@hms.harvard.edu

    Affiliation: Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Published: October 02, 2007
  • DOI: 10.1371/journal.pbio.0050261

About the Authors

Oliver Medvedik, Dudley W Lamming, Keyman D Kim, David A Sinclair
Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: david_sinclair@hms.harvard.edu

Competing Interests

DAS is a founder, director, share holder, and scientific consultant to Sirtris Pharmaceuticals, a company whose goal is to develop sirtuin-activating molecules to treat disease.

Author Contributions

OM, DWL, and DAS conceived and designed the experiments. OM, DWL, and KDK performed the experiments. All authors analyzed the data. OM, DWL, and DAS contributed reagents/materials/analysis tools and wrote the paper.