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Research Article

Emergence of Large-Scale Cell Morphology and Movement from Local Actin Filament Growth Dynamics

  • Catherine I Lacayo,

    Affiliation: Department of Biochemistry, Stanford University, Stanford, California, United States of America

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  • Zachary Pincus,

    Affiliations: Department of Biochemistry, Stanford University, Stanford, California, United States of America, Program in Biomedical Informatics, Stanford University, Stanford, California, United States of America

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  • Martijn M VanDuijn,

    Affiliation: Department of Bioengineering, University of California, Berkeley, California, United States of America

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  • Cyrus A Wilson,

    Affiliation: Department of Biochemistry, Stanford University, Stanford, California, United States of America

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  • Daniel A Fletcher,

    Affiliation: Department of Bioengineering, University of California, Berkeley, California, United States of America

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  • Frank B Gertler,

    Affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Alex Mogilner,

    Affiliations: Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, California, United States of America, Department of Mathematics, University of California Davis, Davis, California, United States of America

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  • Julie A Theriot mail

    To whom correspondence should be addressed. E-mail: theriot@stanford.edu

    Affiliations: Department of Biochemistry, Stanford University, Stanford, California, United States of America, Department of Microbiology and Immunology, Stanford University, Stanford, California, United States of America

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  • Published: August 28, 2007
  • DOI: 10.1371/journal.pbio.0050233

About the Authors

Catherine I Lacayo, Zachary Pincus, Cyrus A Wilson, Julie A Theriot
Department of Biochemistry, Stanford University, Stanford, California, United States of America
Zachary Pincus
Program in Biomedical Informatics, Stanford University, Stanford, California, United States of America
Martijn M VanDuijn, Daniel A Fletcher
Department of Bioengineering, University of California, Berkeley, California, United States of America
Frank B Gertler
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Alex Mogilner
Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, California, United States of America
Alex Mogilner
Department of Mathematics, University of California Davis, Davis, California, United States of America
Julie A Theriot
Department of Microbiology and Immunology, Stanford University, Stanford, California, United States of America

Corresponding Author

Email: theriot@stanford.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CIL and JAT conceived and designed the experiments. CIL and MMVD performed the experiments. CIL, ZP, CAW, and AM analyzed the data. ZP, CAW, DAF, FBG, AM, and JAT contributed reagents/materials/analysis tools. CIL, ZP, AM, and JAT wrote the paper. ZP wrote a methods section. FBG made an intellectual contribution. AM wrote mathematical methods, results, and interpretation.