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Research Article

An Actin-Based Wave Generator Organizes Cell Motility

  • Orion D Weiner mail,

    To whom correspondence should be addressed. E-mail: orion.weiner@ucsf.edu (ODW); marc@hms.harvard.edu (MWK)

    Affiliations: Department of Biochemistry, University of California San Francisco, San Francisco, California, United States of America, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America

    X
  • William A Marganski,

    Affiliation: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Lani F Wu,

    Affiliations: Department of Pharmacology, Southwestern Medical School, Dallas, Texas, United States of America, Green Comprehensive Center for Molecular, Computational, and Systems Biology, Southwestern Medical School, Dallas, Texas, United States of America

    X
  • Steven J Altschuler,

    Affiliations: Department of Pharmacology, Southwestern Medical School, Dallas, Texas, United States of America, Green Comprehensive Center for Molecular, Computational, and Systems Biology, Southwestern Medical School, Dallas, Texas, United States of America

    X
  • Marc W Kirschner mail

    To whom correspondence should be addressed. E-mail: orion.weiner@ucsf.edu (ODW); marc@hms.harvard.edu (MWK)

    Affiliation: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Published: August 14, 2007
  • DOI: 10.1371/journal.pbio.0050221

About the Authors

Orion D Weiner
Department of Biochemistry, University of California San Francisco, San Francisco, California, United States of America
Orion D Weiner
Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America
William A Marganski, Marc W Kirschner
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America
Lani F Wu, Steven J Altschuler
Department of Pharmacology, Southwestern Medical School, Dallas, Texas, United States of America
Lani F Wu, Steven J Altschuler
Green Comprehensive Center for Molecular, Computational, and Systems Biology, Southwestern Medical School, Dallas, Texas, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ODW, WAM, and MWK conceived and designed the experiments. ODW and WAM performed the experiments. ODW, WAM, LFW, and SJA analyzed the data and contributed reagents/materials/analysis tools. ODW and MWK wrote the paper.