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Research Article

Nitroimidazole Action in Entamoeba histolytica: A Central Role for Thioredoxin Reductase

  • David Leitsch,

    Affiliation: Department of Specific Prophylaxis and Tropical Medicine, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria

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  • Daniel Kolarich,

    Affiliation: Department of Chemistry, University of Natural Resources and Applied Life Sciences, Vienna, Austria

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  • Iain B. H Wilson,

    Affiliation: Department of Chemistry, University of Natural Resources and Applied Life Sciences, Vienna, Austria

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  • Friedrich Altmann,

    Affiliation: Department of Chemistry, University of Natural Resources and Applied Life Sciences, Vienna, Austria

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  • Michael Duchêne mail

    To whom correspondence should be addressed. E-mail: michael.duchene@meduniwien.ac.at

    Affiliation: Department of Specific Prophylaxis and Tropical Medicine, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria

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  • Published: July 31, 2007
  • DOI: 10.1371/journal.pbio.0050211

About the Authors

David Leitsch, Michael Duchêne
Department of Specific Prophylaxis and Tropical Medicine, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
Daniel Kolarich, Iain B. H Wilson, Friedrich Altmann
Department of Chemistry, University of Natural Resources and Applied Life Sciences, Vienna, Austria

Corresponding Author

Email: michael.duchene@meduniwien.ac.at

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

DL and MD conceived and designed the experiments. DL and DK performed the experiments. DL, DK, IBHW, and MD analyzed the data. IBHW, FA, and MD contributed reagents/materials/analysis tools. DL, DK, and MD wrote the paper.