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Research Article

Targeted Inhibition of miRNA Maturation with Morpholinos Reveals a Role for miR-375 in Pancreatic Islet Development

  • Wigard P Kloosterman,

    Affiliation: Hubrecht Laboratory-KNAW, Utrecht, The Netherlands

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  • Anne K Lagendijk,

    Affiliation: Hubrecht Laboratory-KNAW, Utrecht, The Netherlands

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  • René F Ketting mail,

    To whom correspondence should be addressed. E-mail: rene@niob.knaw.nl

    Affiliation: Hubrecht Laboratory-KNAW, Utrecht, The Netherlands

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  • Jon D Moulton,

    Affiliation: Gene Tools, Philomath, Oregon, United States of America

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  • Ronald H. A Plasterk

    Affiliation: Hubrecht Laboratory-KNAW, Utrecht, The Netherlands

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  • Published: July 24, 2007
  • DOI: 10.1371/journal.pbio.0050203

About the Authors

Wigard P Kloosterman, Anne K Lagendijk, René F Ketting, Ronald H. A Plasterk
Hubrecht Laboratory-KNAW, Utrecht, The Netherlands
Jon D Moulton
Gene Tools, Philomath, Oregon, United States of America

Corresponding Author

Email: rene@niob.knaw.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

WPK, AKL, RFK, JDM, and RHAP conceived and designed the experiments. WPK and AKL performed the experiments and analyzed data. JDM contributed reagents. WPK, RFK, JDM, and RHAP and wrote the paper.