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Research Article

Rb-Mediated Neuronal Differentiation through Cell-Cycle–Independent Regulation of E2f3a

  • Danian Chen,

    Affiliations: Genetics and Development Division, Toronto Western Research Institute, University Health Network, University of Toronto, Ontario, Canada, Department of Ophthalmology and Visual Science, University of Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada

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  • Rene Opavsky,

    Affiliations: Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio, United States of America, Department of Molecular Genetics, Ohio State University, Columbus, Ohio, United States of America, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

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  • Marek Pacal,

    Affiliations: Genetics and Development Division, Toronto Western Research Institute, University Health Network, University of Toronto, Ontario, Canada, Department of Ophthalmology and Visual Science, University of Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada

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  • Naoyuki Tanimoto,

    Affiliation: Ocular Neurodegeneration Research Group, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Germany

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  • Pamela Wenzel,

    Affiliations: Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio, United States of America, Department of Molecular Genetics, Ohio State University, Columbus, Ohio, United States of America, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

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  • Mathias W Seeliger,

    Affiliation: Ocular Neurodegeneration Research Group, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Germany

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  • Gustavo Leone,

    Affiliations: Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio, United States of America, Department of Molecular Genetics, Ohio State University, Columbus, Ohio, United States of America, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

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  • Rod Bremner mail

    To whom correspondence should be addressed. E-mail: rbremner@uhnres.utoronto.ca

    Affiliations: Genetics and Development Division, Toronto Western Research Institute, University Health Network, University of Toronto, Ontario, Canada, Department of Ophthalmology and Visual Science, University of Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada

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  • Published: July 03, 2007
  • DOI: 10.1371/journal.pbio.0050179

About the Authors

Danian Chen, Marek Pacal, Rod Bremner
Genetics and Development Division, Toronto Western Research Institute, University Health Network, University of Toronto, Ontario, Canada
Danian Chen, Marek Pacal, Rod Bremner
Department of Ophthalmology and Visual Science, University of Toronto, Ontario, Canada
Danian Chen, Marek Pacal, Rod Bremner
Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
Rene Opavsky, Pamela Wenzel, Gustavo Leone
Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio, United States of America
Rene Opavsky, Pamela Wenzel, Gustavo Leone
Department of Molecular Genetics, Ohio State University, Columbus, Ohio, United States of America
Rene Opavsky, Pamela Wenzel, Gustavo Leone
Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America
Naoyuki Tanimoto, Mathias W Seeliger
Ocular Neurodegeneration Research Group, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Germany

Corresponding Author

Email: rbremner@uhnres.utoronto.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

DC and RB conceived and designed the experiments. DC performed most of the experiments. RO, PW, and GL provided the E2f3 floxed and E2f3a KO mice. DC and RB analyzed the data. MP, NT, and MWS performed the ERG analysis. DC and RB wrote the paper.