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Research Article

All β Cells Contribute Equally to Islet Growth and Maintenance

  • Kristen Brennand,

    Affiliations: Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts, United States of America

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  • Danwei Huangfu,

    Affiliations: Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts, United States of America

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  • Doug Melton mail

    To whom correspondence should be addressed. E-mail: dmelton@mcb.harvard.edu

    Affiliations: Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts, United States of America

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  • Published: May 29, 2007
  • DOI: 10.1371/journal.pbio.0050163

About the Authors

Kristen Brennand, Danwei Huangfu, Doug Melton
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America
Kristen Brennand, Danwei Huangfu, Doug Melton
Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America
Kristen Brennand, Danwei Huangfu, Doug Melton
Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: dmelton@mcb.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KB, DH, and DM conceived and designed the experiments. KB and DH performed the experiments and analyzed the data. KB wrote the paper.