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Research Article

Generation of Active Protein Phosphatase 2A Is Coupled to Holoenzyme Assembly

  • Hans Hombauer,

    Affiliation: Department of Medical Biochemistry, Max F. Perutz Laboratories, Medical University of Vienna, Vienna, Austria

    ¤a Current address: Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California, United States of America

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  • David Weismann,

    Affiliation: Department of Medical Biochemistry, Max F. Perutz Laboratories, Medical University of Vienna, Vienna, Austria

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  • Ingrid Mudrak,

    Affiliation: Department of Medical Biochemistry, Max F. Perutz Laboratories, Medical University of Vienna, Vienna, Austria

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  • Claudia Stanzel,

    Affiliation: Department of Medical Biochemistry, Max F. Perutz Laboratories, Medical University of Vienna, Vienna, Austria

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  • Thomas Fellner,

    Affiliation: Department of Medical Biochemistry, Max F. Perutz Laboratories, Medical University of Vienna, Vienna, Austria

    ¤b Current address: Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California, United States of America

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  • Daniel H Lackner,

    Affiliation: Department of Medical Biochemistry, Max F. Perutz Laboratories, Medical University of Vienna, Vienna, Austria

    ¤c Current address: The Sanger Institute, Cambridge, United Kingdom

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  • Egon Ogris mail

    To whom correspondence should be addressed. E-mail: egon.ogris@meduniwien.ac.at

    Affiliation: Department of Medical Biochemistry, Max F. Perutz Laboratories, Medical University of Vienna, Vienna, Austria

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  • Published: June 05, 2007
  • DOI: 10.1371/journal.pbio.0050155

About the Authors

Hans Hombauer, David Weismann, Ingrid Mudrak, Claudia Stanzel, Thomas Fellner, Daniel H Lackner, Egon Ogris
Department of Medical Biochemistry, Max F. Perutz Laboratories, Medical University of Vienna, Vienna, Austria

Corresponding Author

Email: egon.ogris@meduniwien.ac.at

Competing Interests

Egon Ogris serves as a consultant to Millipore/Upstate Corporation.

Author Contributions

HH, DW, and EO conceived and designed the experiments. HH, DW, IM, and CS performed the experiments. HH, DW, IM, CS, and EO analyzed the data. TF and DHL contributed reagents/materials/analysis tools. HH and EO wrote the paper.