Advertisement
Research Article

A KATP Channel-Dependent Pathway within α Cells Regulates Glucagon Release from Both Rodent and Human Islets of Langerhans

  • Patrick E MacDonald mail,

    To whom correspondence should be addressed. E-mail: pmacdonald@bcell.org

    Affiliations: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom, Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

    X
  • Yang Zhang De Marinis,

    Affiliation: Lund University Diabetes Centre, Clinical Research Center, Malmö, Sweden

    X
  • Reshma Ramracheya,

    Affiliation: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom

    X
  • Albert Salehi,

    Affiliation: Lund University Diabetes Centre, Clinical Research Center, Malmö, Sweden

    X
  • Xiaosong Ma,

    Affiliation: Lund University Diabetes Centre, Clinical Research Center, Malmö, Sweden

    X
  • Paul R. V Johnson,

    Affiliation: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom

    X
  • Roger Cox,

    Affiliation: Medical Research Council Mammalian Genetics Unit, Harwell, United Kingdom

    X
  • Lena Eliasson,

    Affiliation: Lund University Diabetes Centre, Clinical Research Center, Malmö, Sweden

    X
  • Patrik Rorsman

    Affiliation: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom

    X
  • Published: May 15, 2007
  • DOI: 10.1371/journal.pbio.0050143

About the Authors

Patrick E MacDonald, Reshma Ramracheya, Paul R. V Johnson, Patrik Rorsman
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
Patrick E MacDonald
Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
Yang Zhang De Marinis, Albert Salehi, Xiaosong Ma, Lena Eliasson
Lund University Diabetes Centre, Clinical Research Center, Malmö, Sweden
Roger Cox
Medical Research Council Mammalian Genetics Unit, Harwell, United Kingdom

Corresponding Author

Email: pmacdonald@bcell.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

PEM, LE, and PR conceived and designed the experiments. PEM, YZDM, RR, AS, XM, and LE performed the experiments. PEM, YZDM, RR, AS, LE, and PR analyzed the data. PRVJ and RC contributed reagents/materials/analysis tools. PEM and PR wrote the paper.