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Research Article

Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence

  • João F Passos,

    Affiliations: Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom, Center for Integrated Systems Biology of Ageing and Nutrition, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Gabriele Saretzki,

    Affiliations: Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom, Crucible Laboratory, Life Knowledge Park, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Shaheda Ahmed,

    Affiliations: Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom, Crucible Laboratory, Life Knowledge Park, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Glyn Nelson,

    Affiliations: Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom, Center for Integrated Systems Biology of Ageing and Nutrition, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Torsten Richter,

    Affiliation: Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Heiko Peters,

    Affiliation: Institute of Human Genetics, International Centre for Life, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Ilka Wappler,

    Affiliation: Institute of Human Genetics, International Centre for Life, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Matthew J Birket,

    Affiliation: School of Clinical and Laboratory Sciences, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Graham Harold,

    Affiliation: Crucible Laboratory, Life Knowledge Park, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Karin Schaeuble,

    Affiliation: Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Mark A Birch-Machin,

    Affiliation: School of Clinical and Laboratory Sciences, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Thomas B. L Kirkwood,

    Affiliations: Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom, Center for Integrated Systems Biology of Ageing and Nutrition, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Thomas von Zglinicki mail

    To whom correspondence should be addressed. E-mail: t.vonzglinicki@ncl.ac.uk

    Affiliations: Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom, Center for Integrated Systems Biology of Ageing and Nutrition, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Published: May 01, 2007
  • DOI: 10.1371/journal.pbio.0050110

About the Authors

João F Passos, Gabriele Saretzki, Shaheda Ahmed, Glyn Nelson, Torsten Richter, Karin Schaeuble, Thomas B. L Kirkwood, Thomas von Zglinicki
Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom
João F Passos, Glyn Nelson, Thomas B. L Kirkwood, Thomas von Zglinicki
Center for Integrated Systems Biology of Ageing and Nutrition, University of Newcastle, Newcastle upon Tyne, United Kingdom
Gabriele Saretzki, Shaheda Ahmed, Graham Harold
Crucible Laboratory, Life Knowledge Park, University of Newcastle, Newcastle upon Tyne, United Kingdom
Heiko Peters, Ilka Wappler
Institute of Human Genetics, International Centre for Life, University of Newcastle, Newcastle upon Tyne, United Kingdom
Matthew J Birket, Mark A Birch-Machin
School of Clinical and Laboratory Sciences, University of Newcastle, Newcastle upon Tyne, United Kingdom

Corresponding Author

Email: t.vonzglinicki@ncl.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JFP, MABM, TBLK, and TvZ conceived and designed the experiments. JFP, GS, SA, GN, TR, HP, IW, MJB, GH, and KS performed the experiments. JFP, GS, HP, and TvZ analyzed the data. TvZ wrote the paper.