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Research Article

Understanding the Evolutionary Fate of Finite Populations: The Dynamics of Mutational Effects

  • Olin K Silander equal contributor mail,

    equal contributor Contributed equally to this work with: Olin K Silander, Olivier Tenaillon

    To whom correspondence should be addressed. E-mail: olin.silander@env.ethz.ch

    Affiliations: Division of Biology, University of California San Diego, La Jolla, California, United States of America, Institute of Integrative Biology, Eidgenössische Technische Hochschule (ETH) Zurich, Zurich, Switzerland

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  • Olivier Tenaillon equal contributor,

    equal contributor Contributed equally to this work with: Olin K Silander, Olivier Tenaillon

    Affiliations: Division of Biology, University of California San Diego, La Jolla, California, United States of America, INSERM U722, Faculté de Médecine Xavier Bichat, Paris, France, Université Paris 7, Paris, France

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  • Lin Chao

    Affiliation: Division of Biology, University of California San Diego, La Jolla, California, United States of America

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  • Published: April 03, 2007
  • DOI: 10.1371/journal.pbio.0050094

About the Authors

Olin K Silander, Olivier Tenaillon, Lin Chao
Division of Biology, University of California San Diego, La Jolla, California, United States of America
Olin K Silander
Institute of Integrative Biology, Eidgenössische Technische Hochschule (ETH) Zurich, Zurich, Switzerland
Olivier Tenaillon
INSERM U722, Faculté de Médecine Xavier Bichat, Paris, France
Olivier Tenaillon
Université Paris 7, Paris, France

Corresponding Author

Email: olin.silander@env.ethz.ch

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

OKS, OT, and LC contributed to the conception of the experiments. OKS and OT performed the experimental evolution and the mutation accumulation. OKS performed the maximum likelihood analysis of the mutation accumulation data and the analysis of the sequence data. OT performed the simulation analyses of substitution rates.