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Research Article

Modification of a Hydrophobic Layer by a Point Mutation in Syntaxin 1A Regulates the Rate of Synaptic Vesicle Fusion

  • Robert D Lagow,

    Affiliation: Section of Neurobiology and Institute for Neuroscience, University of Texas at Austin, Austin, Texas, United States of America

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  • Hong Bao,

    Affiliation: Section of Neurobiology and Institute for Neuroscience, University of Texas at Austin, Austin, Texas, United States of America

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  • Evan N Cohen,

    Affiliation: Section of Neurobiology and Institute for Neuroscience, University of Texas at Austin, Austin, Texas, United States of America

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  • Richard W Daniels,

    Affiliation: Section of Neurobiology and Institute for Neuroscience, University of Texas at Austin, Austin, Texas, United States of America

    ¤a Current address: Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Aleksej Zuzek,

    Affiliation: Section of Neurobiology and Institute for Neuroscience, University of Texas at Austin, Austin, Texas, United States of America

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  • Wade H Williams,

    Affiliation: Section of Neurobiology and Institute for Neuroscience, University of Texas at Austin, Austin, Texas, United States of America

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  • Gregory T Macleod,

    Affiliation: Section of Neurobiology and Institute for Neuroscience, University of Texas at Austin, Austin, Texas, United States of America

    ¤b Current address: Division of Neurobiology, University of Arizona, Tucson, Arizona, United States of America

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  • R. Bryan Sutton,

    Affiliation: Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Bing Zhang mail

    To whom correspondence should be addressed. E-mail: bzhang@mail.utexas.edu

    Affiliation: Section of Neurobiology and Institute for Neuroscience, University of Texas at Austin, Austin, Texas, United States of America

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  • Published: March 06, 2007
  • DOI: 10.1371/journal.pbio.0050072

About the Authors

Robert D Lagow, Hong Bao, Evan N Cohen, Richard W Daniels, Aleksej Zuzek, Wade H Williams, Gregory T Macleod, Bing Zhang
Section of Neurobiology and Institute for Neuroscience, University of Texas at Austin, Austin, Texas, United States of America
R. Bryan Sutton
Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas, United States of America

Corresponding Author

Email: bzhang@mail.utexas.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

RDL, HB, and RBS contributed equally to this work. RDL, HB, and BZ designed the experiment. RDL, HB, ENC, RWD, AZ, WHW, GTM, RBS, and BZ performed the experiment. RDL, HB, AZ, RBS, and BZ analyzed the results. BZ wrote the paper. RWD and RBS contributed to paper revision.