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Research Article

Als3 Is a Candida albicans Invasin That Binds to Cadherins and Induces Endocytosis by Host Cells

  • Quynh T Phan,

    Affiliation: Department of Medicine, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, United States of America

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  • Carter L Myers,

    Affiliation: Department of Medicine, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, United States of America

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  • Yue Fu,

    Affiliations: Department of Medicine, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, United States of America, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Donald C Sheppard,

    Affiliation: Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada

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  • Michael R Yeaman,

    Affiliations: Department of Medicine, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, United States of America, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • William H Welch,

    Affiliation: Department of Biochemistry, University of Nevada Reno, Reno, Nevada, United States of America

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  • Ashraf S Ibrahim,

    Affiliations: Department of Medicine, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, United States of America, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • John E Edwards Jr.,

    Affiliations: Department of Medicine, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, United States of America, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Scott G Filler mail

    To whom correspondence should be addressed. E-mail: sfiller@ucla.edu

    Affiliations: Department of Medicine, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, United States of America, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Published: February 20, 2007
  • DOI: 10.1371/journal.pbio.0050064

About the Authors

Quynh T Phan, Carter L Myers, Yue Fu, Michael R Yeaman, Ashraf S Ibrahim, John E Edwards Jr., Scott G Filler
Department of Medicine, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, United States of America
Yue Fu, Michael R Yeaman, Ashraf S Ibrahim, John E Edwards Jr., Scott G Filler
David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
Donald C Sheppard
Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
William H Welch
Department of Biochemistry, University of Nevada Reno, Reno, Nevada, United States of America

Corresponding Author

Email: sfiller@ucla.edu

Competing Interests

YF, MRY, ASI, JEE, and SGF have equity in NovaDigm Therapeutics, Inc.

Author Contributions

QTP, CLM, YF, DCS, MRY, WHW, ASI, JEE, and SGF conceived and designed the experiments. QTP, CLM, YF, WHW, and ASI performed the experiments. QTP, CLM, YF, DCS, MRY, WHW, and SGF analyzed the data. WHW and ASI contributed reagents/materials/analysis tools. DCS, MRY, JEE, and SGF wrote the paper.