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Research Article

Discrete States of a Protein Interaction Network Govern Interphase and Mitotic Microtubule Dynamics

  • Philipp Niethammer equal contributor,

    equal contributor Contributed equally to this work with: Philipp Niethammer, Iva Kronja

    Affiliations: Cell Biology and Biophysics Department, European Molecular Biology Laboratory, Heidelberg, Germany, Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Iva Kronja equal contributor,

    equal contributor Contributed equally to this work with: Philipp Niethammer, Iva Kronja

    Affiliation: Cell Biology and Biophysics Department, European Molecular Biology Laboratory, Heidelberg, Germany

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  • Stefanie Kandels-Lewis,

    Affiliation: Cell Biology and Biophysics Department, European Molecular Biology Laboratory, Heidelberg, Germany

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  • Sonja Rybina,

    Affiliation: Cell Biology and Biophysics Department, European Molecular Biology Laboratory, Heidelberg, Germany

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  • Philippe Bastiaens mail,

    To whom correspondence should be addressed. E-mail: bastiaen@embl.de (PB); karsenti@embl.de (EK)

    Affiliation: Cell Biology and Biophysics Department, European Molecular Biology Laboratory, Heidelberg, Germany

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  • Eric Karsenti mail

    To whom correspondence should be addressed. E-mail: bastiaen@embl.de (PB); karsenti@embl.de (EK)

    Affiliation: Cell Biology and Biophysics Department, European Molecular Biology Laboratory, Heidelberg, Germany

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  • Published: January 16, 2007
  • DOI: 10.1371/journal.pbio.0050029

About the Authors

Philipp Niethammer, Iva Kronja, Stefanie Kandels-Lewis, Sonja Rybina, Philippe Bastiaens, Eric Karsenti
Cell Biology and Biophysics Department, European Molecular Biology Laboratory, Heidelberg, Germany
Philipp Niethammer
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

PN, IK, EK, and PB conceived and designed the experiments. PN and IK performed the experiments. PN, IK, PB, and EK analyzed the data. PN, SKL, and SR contributed reagents/materials/analysis tools. PN, IK, PB, and EK wrote the paper.