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Research Article

Rate of Evolution in Brain-Expressed Genes in Humans and Other Primates

  • Hurng-Yi Wang,

    Affiliations: Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America

    ¤ Current address: Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan

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  • Huan-Chieh Chien,

    Affiliation: Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan

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  • Naoki Osada,

    Affiliation: Division of Biomedical Research Resources, National Institute of Biomedical Innovation, Osaka, Japan

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  • Katsuyuki Hashimoto,

    Affiliation: Division of Genetic Resources, National Institute of Infectious Diseases, Tokyo, Japan

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  • Sumio Sugano,

    Affiliation: Laboratory of Functional Genomics, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan

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  • Takashi Gojobori,

    Affiliation: Center of Information Biology, National Institute of Genetics, Mishima, Japan

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  • Chen-Kung Chou,

    Affiliation: Department of Life Science, Chang Gung University, Tao-Yuan, Taiwan

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  • Shih-Feng Tsai,

    Affiliation: Division of Molecular and Genomic Medicine, National Health Research Institute, Miaoli, Taiwan

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  • Chung-I Wu mail,

    To whom correspondence should be addressed. E-mail: ciwu@uchicago.edu (CIW); ckshen@ccvax.sinica.edu.tw (CKJS)

    Affiliation: Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America

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  • C.-K. James Shen mail

    To whom correspondence should be addressed. E-mail: ciwu@uchicago.edu (CIW); ckshen@ccvax.sinica.edu.tw (CKJS)

    Affiliation: Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan

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  • Published: December 26, 2006
  • DOI: 10.1371/journal.pbio.0050013

About the Authors

Hurng-Yi Wang, Huan-Chieh Chien, C.-K. James Shen
Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
Hurng-Yi Wang, Chung-I Wu
Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America
Naoki Osada
Division of Biomedical Research Resources, National Institute of Biomedical Innovation, Osaka, Japan
Katsuyuki Hashimoto
Division of Genetic Resources, National Institute of Infectious Diseases, Tokyo, Japan
Sumio Sugano
Laboratory of Functional Genomics, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan
Takashi Gojobori
Center of Information Biology, National Institute of Genetics, Mishima, Japan
Chen-Kung Chou
Department of Life Science, Chang Gung University, Tao-Yuan, Taiwan
Shih-Feng Tsai
Division of Molecular and Genomic Medicine, National Health Research Institute, Miaoli, Taiwan

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KH, CKC, SFT,CIW, and CKJS conceived and designed the experiments. HYW, HCC, and NO performed the experiments. HYW, HCC, NO, and CKJS analyzed the data. KH, SS, TG, CKC, and SFT contributed reagents/materials/analysis tools. HYW, CIW, and CKJS wrote the paper.